Search Results

Overview

Uniprot ID	Q8NHM5
Protein Name	Lysine-specific demethylase 2B
Gene Name	KDM2B
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
596	LGPASAVKLAANRTT
805	VHLRKKRKYEKPQEL
884	DRMALANKPLRRFKQ

Function

Histone demethylase that demethylates 'Lys-4' and 'Lys-36' of histone H3, thereby playing a central role in histone code (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially demethylates trimethylated H3 'Lys-4' and dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36' (PubMed:16362057, PubMed:17994099, PubMed:26237645). Preferentially binds the transcribed region of ribosomal RNA and represses the transcription of ribosomal RNA genes which inhibits cell growth and proliferation (PubMed:16362057, PubMed:17994099). May also serve as a substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (Probable)

Protein Sequence

10 MAGPQMGGSA 20 EDHPPRKRHA 30 AEKQKKKTVI 40 YTKCFEFESA 50 TQRPIDRQRY 60 DENEDLSDVE 70 EIVSVRGFSL 80 EEKLRSQLYQ 90 GDFVHAMEGK 100 DFNYEYVQRE 110 ALRVPLIFRE 120 KDGLGIKMPD 130 PDFTVRDVKL 140 LVGSRRLVDV 150 MDVNTQKGTE 160 MSMSQFVRYY 170 ETPEAQRDKL 180 YNVISLEFSH 190 TKLEHLVKRP 200 TVVDLVDWVD 210 NMWPQHLKEK 220 QTEATNAIAE 230 MKYPKVKKYC 240 LMSVKGCFTD 250 FHIDFGGTSV 260 WYHVFRGGKI 270 FWLIPPTLHN 280 LALYEEWVLS 290 GKQSDIFLGD 300 RVERCQRIEL 310 KQGYTFFIPS 320 GWIHAVYTPV 330 DSLVFGGNIL 340 HSFNVPMQLR 350 IYEIEDRTRV 360 QPKFRYPFYY 370 EMCWYVLERY 380 VYCVTQRSHL 390 TQEYQRESML 400 IDAPRKPSID 410 GFSSDSWLEM 420 EEEACDQQPQ 430 EEEEKDEEGE 440 GRDRAPKPPT 450 DGSTSPTSTP 460 SEDQEALGKK 470 PKAPALRFLK 480 RTLSNESEES 490 VKSTTLAVDY 500 PKTPTGSPAT 510 EVSAKWTHLT 520 EFELKGLKAL 530 VEKLESLPEN 540 KKCVPEGIED 550 PQALLEGVKN 560 VLKEHADDDP 570 SLAITGVPVV 580 TWPKKTPKNR 590 AVGRPKGKLG 600 PASAVKLAAN 610 RTTAGARRRR 620 TRCRKCEACL 630 RTECGECHFC 640 KDMKKFGGPG 650 RMKQSCIMRQ 660 CIAPVLPHTA 670 VCLVCGEAGK 680 EDTVEEEEGK 690 FNLMLMECSI 700 CNEIIHPGCL 710 KIKESEGVVN 720 DELPNCWECP 730 KCNHAGKTGK 740 QKRGPGFKYA 750 SNLPGSLLKE 760 QKMNRDNKEG 770 QEPAKRRSEC 780 EEAPRRRSDE 790 HSKKVPPDGL 800 LRRKSDDVHL 810 RKKRKYEKPQ 820 ELSGRKRASS 830 LQTSPGSSSH 840 LSPRPPLGSS 850 LSPWWRSSLT 860 YFQQQLKPGK 870 EDKLFRKKRR 880 SWKNAEDRMA 890 LANKPLRRFK 900 QEPEDELPEA 910 PPKTRESDHS 920 RSSSPTAGPS 930 TEGAEGPEEK 940 KKVKMRRKRR 950 LPNKELSREL 960 SKELNHEIQR 970 TENSLANENQ 980 QPIKSEPESE 990 GEEPKRPPGI 1000 CERPHRFSKG 1010 LNGTPRELRH 1020 QLGPSLRSPP 1030 RVISRPPPSV 1040 SPPKCIQMER 1050 HVIRPPPISP 1060 PPDSLPLDDG 1070 AAHVMHREVW 1080 MAVFSYLSHQ 1090 DLCVCMRVCR 1100 TWNRWCCDKR 1110 LWTRIDLNHC 1120 KSITPLMLSG 1130 IIRRQPVSLD 1140 LSWTNISKKQ 1150 LSWLINRLPG 1160 LRDLVLSGCS 1170 WIAVSALCSS 1180 SCPLLRTLDV 1190 QWVEGLKDAQ 1200 MRDLLSPPTD 1210 NRPGQMDNRS 1220 KLRNIVELRL 1230 AGLDITDASL 1240 RLIIRHMPLL 1250 SKLHLSYCNH 1260 VTDQSINLLT 1270 AVGTTTRDSL 1280 TEINLSDCNK 1290 VTDQCLSFFK 1300 RCGNICHIDL 1310 RYCKQVTKEG 1320 CEQFIAEMSV 1330 SVQFGQVEEK LLQKLS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0000785	chromatin
Cellular Component	GO:0005730	nucleolus
Cellular Component	GO:0005654	nucleoplasm
Cellular Component	GO:0005634	nucleus
Cellular Component	GO:0031519	PcG protein complex
Molecular Function	GO:0003677	DNA binding
Molecular Function	GO:0032452	histone demethylase activity
Molecular Function	GO:0051864	histone H3K36 demethylase activity
Molecular Function	GO:0140680	histone H3K36me/H3K36me2 demethylase activity
Molecular Function	GO:0000978	RNA polymerase II cis-regulatory region sequence-specific DNA binding
Molecular Function	GO:0019843	rRNA binding
Molecular Function	GO:0003712	transcription coregulator activity
Molecular Function	GO:0045322	unmethylated CpG binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:0006338	chromatin remodeling
Biological Process	GO:0006351	DNA-templated transcription
Biological Process	GO:0048596	embryonic camera-type eye morphogenesis
Biological Process	GO:0030900	forebrain development
Biological Process	GO:0021592	fourth ventricle development
Biological Process	GO:0031507	heterochromatin formation
Biological Process	GO:0030902	hindbrain development
Biological Process	GO:0021993	initiation of neural tube closure
Biological Process	GO:0021670	lateral ventricle development
Biological Process	GO:0030901	midbrain development
Biological Process	GO:0021555	midbrain-hindbrain boundary morphogenesis
Biological Process	GO:0045892	negative regulation of DNA-templated transcription
Biological Process	GO:2000178	negative regulation of neural precursor cell proliferation
Biological Process	GO:0043524	negative regulation of neuron apoptotic process
Biological Process	GO:0000122	negative regulation of transcription by RNA polymerase II
Biological Process	GO:0006357	regulation of transcription by RNA polymerase II
Biological Process	GO:0031146	SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
Biological Process	GO:0007283	spermatogenesis
Biological Process	GO:0021678	third ventricle development

Reference

[1] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.