Search Results
Overview
| Uniprot ID | Q8NHP1 |
|---|---|
| Protein Name | Aflatoxin B1 aldehyde reductase member 4 |
| Gene Name | AKR7L |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 100 | SQLETSLKRLQCPRV |
Function
Can reduce the dialdehyde protein-binding form of aflatoxin B1 (AFB1) to the non-binding AFB1 dialcohol. May be involved in protection of liver against the toxic and carcinogenic effects of AFB1, a potent hepatocarcinogen (By similarity)
Protein Sequence
10
MSRQLSRARP
20
ATVLGAMEMG
30
RRMDAPTSAA
40
VTRAFLERGH
50
TEIDTAFLYS
60
DGQSETILGG
70
LGLRMGSSDC
80
RVKIATKANP
90
WIGNSLKPDS
100
VRSQLETSLK
110
RLQCPRVDLF
120
YLHAPDHSAP
130
VEETLRACHQ
140
LHQEGKFVEL
150
GLSNYAAWEV
160
AEICTLCKSN
170
GWILPTVYQG
180
MYSATTRQVE
190
TELFPCLRHF
200
GLRFYAYNPL
210
AGGLLTGKYK
220
YEDKDGKQPV
230
GRFFGTQWAE
240
IYRNHFWKEH
250
HFEGIALVEK
260
ALQAAYGASA
270
PSMTSAALRW
280
MYHHSQLQGA
290
HGDAVILGMS
300
SLEQLEQNLA
310
AAEEGPLEPA
320
VVDAFNQAWH
330
LFAHECPNYF
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0070062 | extracellular exosome |
| Molecular Function | GO:0008106 | alcohol dehydrogenase (NADP+) activity |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.