Search Results
Overview
| Uniprot ID | Q8NHS2 |
|---|---|
| Protein Name | Aspartate aminotransferase, cytoplasmic 2 |
| Gene Name | GOT1L1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 325 | VENIMLTKEKVKEKL |
Function
Catalyzes the conversion of L-aspartate and 2-oxoglutarate to L-glutamate and oxaloacetate (PubMed:25287256). It has been proposed to exhibit aspartate racemase activity, but this function remains debated and lacks strong experimental support (PubMed:25287256)
Protein Sequence
10
MPTLSVFMDV
20
PLAHKLEGSL
30
LKTYKQDDYP
40
NKIFLAYRVC
50
MTNEGHPWVS
60
LVVQKTRLQI
70
SQDPSLNYEY
80
LPTMGLKSFI
90
QASLALLFGK
100
HSQAIVENRV
110
GGVHTVGDSG
120
AFQLGVQFLR
130
AWHKDARIVY
140
IISSQKELHG
150
LVFQDMGFTV
160
YEYSVWDPKK
170
LCMDPDILLN
180
VVEQIPHGCV
190
LVMGNIIDCK
200
LTPSGWAKLM
210
SMIKSKQIFP
220
FFDIPCQGLY
230
TSDLEEDTRI
240
LQYFVSQGFE
250
FFCSQSLSKN
260
FGIYDEGVGM
270
LVVVAVNNQQ
280
LLCVLSQLEG
290
LAQALWLNPP
300
NTGARVITSI
310
LCNPALLGEW
320
KQSLKEVVEN
330
IMLTKEKVKE
340
KLQLLGTPGS
350
WGHITEQSGT
360
HGYLGLNSQQ
370
VEYLVRKKHI
380
YIPKNGQINF
390
SCINANNINY
400
ITEGINEAVL
410
LTESSEMCLP
420
KEKKTLIGIK
L
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0004069 | L-aspartate:2-oxoglutarate aminotransferase activity |
| Molecular Function | GO:0030170 | pyridoxal phosphate binding |
| Biological Process | GO:0006532 | L-aspartate biosynthetic process |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.