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Overview

Uniprot IDQ8NI08
Protein NameNuclear receptor coactivator 7
Gene NameNCOA7
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
389 HGSPTVTKLSKEPSD

Function

Transcriptional coactivator which enhances the transcriptional activities of several nuclear receptors including ESR1, THRB, PPARG and RARA (PubMed:11971969). Inhibits the activity of the vacuolar-type ATPase (V-ATPase) by inducing disassembly of the V-ATPase complex (PubMed:38593795). Protects the Golgi apparatus lumen from excess acidification by inhibiting V-ATPase ATP hydrolytic activity through interaction with V-ATPase catalytic subunit ATP6V1A, maintaining optimal conditions for glycosylation enzymes (By similarity). Required to stabilize V-ATPase V1 subunits ATP6V1B2 and ATP6V1A at membrane sites (By similarity). Involved in protection against oxidative damage (PubMed:17391516, PubMed:25330068). Involved in urine acidification (By similarity)

Protein Sequence

10 MDTKEEKKER 20 KQSYFARLKK 30 KKQAKQNAET 40 ASAVATRTHT 50 GKEDNNTVVL 60 EPDKCNIAVE 70 EEYMTDEKKK 80 RKSNQLKEIR 90 RTELKRYYSI 100 DDNQNKTHDK 110 KEKKMVVQKP 120 HGTMEYTAGN 130 QDTLNSIALK 140 FNITPNKLVE 150 LNKLFTHTIV 160 PGQVLFVPDA 170 NSPSSTLRLS 180 SSSPGATVSP 190 SSSDAEYDKL 200 PDADLARKAL 210 KPIERVLSST 220 SEEDEPGVVK 230 FLKMNCRYFT 240 DGKGVVGGVM 250 IVTPNNIMFD 260 PHKSDPLVIE 270 NGCEEYGLIC 280 PMEEVVSIAL 290 YNDISHMKIK 300 DALPSDLPQD 310 LCPLYRPGEW 320 EDLASEKDIN 330 PFSKFKSINK 340 EKRQQNGEKI 350 MTSDSRPIVP 360 LEKSTGHTPT 370 KPSGSSVSEK 380 LKKLDSSRET 390 SHGSPTVTKL 400 SKEPSDTSSA 410 FESTAKENFL 420 GEDDDFVDLE 430 ELSSQTGGGM 440 HKKDTLKECL 450 SLDPEERKKA 460 ESQINNSAVE 470 MQVQSALAFL 480 GTENDVELKG 490 ALDLETCEKQ 500 DIMPEVDKQS 510 GSPESRVENT 520 LNIHEDLDKV 530 KLIEYYLTKN 540 KEGPQVSENL 550 QKTELSDGKS 560 IEPGGIDITL 570 SSSLSQAGDP 580 ITEGNKEPDK 590 TWVKKGEPLP 600 VKLNSSTEAN 610 VIKEALDSSL 620 ESTLDNSCQG 630 AQMDNKSEVQ 640 LWLLKRIQVP 650 IEDILPSKEE 660 KSKTPPMFLC 670 IKVGKPMRKS 680 FATHTAAMVQ 690 QYGKRRKQPE 700 YWFAVPRERV 710 DHLYTFFVQW 720 SPDVYGKDAK 730 EQGFVVVEKE 740 ELNMIDNFFS 750 EPTTKSWEII 760 TVEEAKRRKS 770 TCSYYEDEDE 780 EVLPVLRPHS 790 ALLENMHIEQ 800 LARRLPARVQ 810 GYPWRLAYST 820 LEHGTSLKTL 830 YRKSASLDSP 840 VLLVIKDMDN 850 QIFGAYATHP 860 FKFSDHYYGT 870 GETFLYTFSP 880 HFKVFKWSGE 890 NSYFINGDIS 900 SLELGGGGGR 910 FGLWLDADLY 920 HGRSNSCSTF 930 NNDILSKKED 940 FIVQDLEVWA FD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016922 nuclear receptor binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0006979 response to oxidative stress

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.