Search Results

Overview

Uniprot IDQ8NI35
Protein NameInaD-like protein
Gene NamePATJ
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
561 AELQKYSKLLPIHTL

Function

Scaffolding protein that facilitates the localization of proteins to the cell membrane (PubMed:11927608, PubMed:16678097, PubMed:22006950). Required for the correct formation of tight junctions and epithelial apico-basal polarity (PubMed:11927608, PubMed:16678097). Acts (via its L27 domain) as an apical connector and elongation factor for multistranded TJP1/ZO1 condensates that form a tight junction belt, thereby required for the formation of the tight junction-mediated cell barrier (By similarity). Positively regulates epithelial cell microtubule elongation and cell migration, possibly via facilitating localization of PRKCI/aPKC and PAR3D/PAR3 at the leading edge of migrating cells (By similarity). Plays a role in the correct reorientation of the microtubule-organizing center during epithelial migration (By similarity). May regulate the surface expression and/or function of ASIC3 in sensory neurons (By similarity). May recruit ARHGEF18 to apical cell-cell boundaries (PubMed:22006950)

Protein Sequence

10 MPENPATDKL 20 QVLQVLDRLK 30 MKLQEKGDTS 40 QNEKLSMFYE 50 TLKSPLFNQI 60 LTLQQSIKQL 70 KGQLNHIPSD 80 CSANFDFSRK 90 GLLVFTDGSI 100 TNGNVHRPSN 110 NSTVSGLFPW 120 TPKLGNEDFN 130 SVIQQMAQGR 140 QIEYIDIERP 150 STGGLGFSVV 160 ALRSQNLGKV 170 DIFVKDVQPG 180 SVADRDQRLK 190 ENDQILAINH 200 TPLDQNISHQ 210 QAIALLQQTT 220 GSLRLIVARE 230 PVHTKSSTSS 240 SLNDTTLPET 250 VCWGHVEEVE 260 LINDGSGLGF 270 GIVGGKTSGV 280 VVRTIVPGGL 290 ADRDGRLQTG 300 DHILKIGGTN 310 VQGMTSEQVA 320 QVLRNCGNSV 330 RMLVARDPAG 340 DISVTPPAPA 350 ALPVALPTVA 360 SKGPGSDSSL 370 FETYNVELVR 380 KDGQSLGIRI 390 VGYVGTSHTG 400 EASGIYVKSI 410 IPGSAAYHNG 420 HIQVNDKIVA 430 VDGVNIQGFA 440 NHDVVEVLRN 450 AGQVVHLTLV 460 RRKTSSSTSP 470 LEPPSDRGTV 480 VEPLKPPALF 490 LTGAVETETN 500 VDGEDEEIKE 510 RIDTLKNDNI 520 QALEKLEKVP 530 DSPENELKSR 540 WENLLGPDYE 550 VMVATLDTQI 560 ADDAELQKYS 570 KLLPIHTLRL 580 GVEVDSFDGH 590 HYISSIVSGG 600 PVDTLGLLQP 610 EDELLEVNGM 620 QLYGKSRREA 630 VSFLKEVPPP 640 FTLVCCRRLF 650 DDEASVDEPR 660 RTETSLPETE 670 VDHNMDVNTE 680 EDDDGELALW 690 SPEVKIVELV 700 KDCKGLGFSI 710 LDYQDPLDPT 720 RSVIVIRSLV 730 ADGVAERSGG 740 LLPGDRLVSV 750 NEYCLDNTSL 760 AEAVEILKAV 770 PPGLVHLGIC 780 KPLVEDNEEE 790 SCYILHSSSN 800 EDKTEFSGTI 810 HDINSSLILE 820 APKGFRDEPY 830 FKEELVDEPF 840 LDLGKSFHSQ 850 QKEIEQSKEA 860 WEMHEFLTPR 870 LQEMDEEREI 880 LVDEEYELYQ 890 DPSPSMELYP 900 LSHIQEATPV 910 PSVNELHFGT 920 QWLHDNEPSE 930 SQEARTGRTV 940 YSQEAQPYGY 950 CPENVMKENF 960 VMESLPSVPS 970 TEGNSQQGRF 980 DDLENLNSLA 990 KTSLDLGMIP 1000 NDVQGPSLLI 1010 DLPVVAQRRE 1020 QEDLPLYQHQ 1030 ATRVISKASA 1040 YTGMLSSRYA 1050 TDTCELPERE 1060 EGEGEETPNF 1070 SHWGPPRIVE 1080 IFREPNVSLG 1090 ISIVGGQTVI 1100 KRLKNGEELK 1110 GIFIKQVLED 1120 SPAGKTNALK 1130 TGDKILEVSG 1140 VDLQNASHSE 1150 AVEAIKNAGN 1160 PVVFIVQSLS 1170 STPRVIPNVH 1180 NKANKITGNQ 1190 NQDTQEKKEK 1200 RQGTAPPPMK 1210 LPPPYKALTD 1220 DSDENEEEDA 1230 FTDQKIRQRY 1240 ADLPGELHII 1250 ELEKDKNGLG 1260 LSLAGNKDRS 1270 RMSIFVVGIN 1280 PEGPAAADGR 1290 MRIGDELLEI 1300 NNQILYGRSH 1310 QNASAIIKTA 1320 PSKVKLVFIR 1330 NEDAVNQMAV 1340 TPFPVPSSSP 1350 SSIEDQSGTE 1360 PISSEEDGSV 1370 EVGIKQLPES 1380 ESFKLAVSQM 1390 KQQKYPTKVS 1400 FSSQEIPLAP 1410 ASSYHSTDAD 1420 FTGYGGFQAP 1430 LSVDPATCPI 1440 VPGQEMIIEI 1450 SKGRSGLGLS 1460 IVGGKDTPLN 1470 AIVIHEVYEE 1480 GAAARDGRLW 1490 AGDQILEVNG 1500 VDLRNSSHEE 1510 AITALRQTPQ 1520 KVRLVVYRDE 1530 AHYRDEENLE 1540 IFPVDLQKKA 1550 GRGLGLSIVG 1560 KRNGSGVFIS 1570 DIVKGGAADL 1580 DGRLIQGDQI 1590 LSVNGEDMRN 1600 ASQETVATIL 1610 KCAQGLVQLE 1620 IGRLRAGSWT 1630 SARTTSQNSQ 1640 GSQQSAHSSC 1650 HPSFAPVITG 1660 LQNLVGTKRV 1670 SDPSQKNSGT 1680 DMEPRTVEIN 1690 RELSDALGIS 1700 IAGGRGSPLG 1710 DIPVFIAMIQ 1720 ASGVAARTQK 1730 LKVGDRIVSI 1740 NGQPLDGLSH 1750 ADVVNLLKNA 1760 YGRIILQVVA 1770 DTNISAIAAQ 1780 LENMSTGYHL 1790 GSPTAEHHPE 1800 DTEEQLQMTA D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0043296 apical junction complex
Cellular Component GO:0045177 apical part of cell
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0005923 bicellular tight junction
Cellular Component GO:0030054 cell junction
Cellular Component GO:0034451 centriolar satellite
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Biological Process GO:0035089 establishment of apical/basal cell polarity
Biological Process GO:0045197 establishment or maintenance of epithelial cell apical/basal polarity
Biological Process GO:0035556 intracellular signal transduction
Biological Process GO:0120192 tight junction assembly

Reference

PMID: N/A