Search Results

Overview

Uniprot IDQ8QZS1
Protein Name3-hydroxyisobutyryl-CoA hydrolase, mitochondrial
Gene NameHibch
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
100 FCAGGDIKALSEAKK
220 THFVDSEKLRVLEEE
249 VLESYHAKSKMDQDK
256 KSKMDQDKSIIFEEH
296 PFAIEQMKVINKMSP
300 EQMKVINKMSPTSLK
352 VRAVLIDKDQTPKWK
91 IIKGAGGKAFCAGGD

Function

Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA (By similarity)

Protein Sequence

10 MGQPYAWRLL 20 SRVSSFRRAS 30 VILQHLRMSM 40 HTEAAEVLLE 50 RRGCGGVITL 60 NRPKFLNALS 70 LNMIRQIYPQ 80 LKTWEQDPDT 90 FLIIIKGAGG 100 KAFCAGGDIK 110 ALSEAKKARQ 120 NLTQDLFREE 130 YILNNAIASC 140 QKPYVALIDG 150 ITMGGGVGLS 160 VHGQFRVATE 170 RSLFAMPETG 180 IGLFPDVGGG 190 YFLPRLQGKL 200 GYFLALTGYR 210 LKGRDVHRAG 220 IATHFVDSEK 230 LRVLEEELLA 240 LKSPSAEDVA 250 GVLESYHAKS 260 KMDQDKSIIF 270 EEHMDKINSC 280 FSANTVEQII 290 ENLRQDGSPF 300 AIEQMKVINK 310 MSPTSLKITL 320 RQLMEGSSKT 330 LQEVLIMEYR 340 ITQACMEGHD 350 FHEGVRAVLI 360 DKDQTPKWKP 370 ANLKDVTDED 380 LNSYFKSLGS SDLKF

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0003860 3-hydroxyisobutyryl-CoA hydrolase activity
Biological Process GO:0006574 L-valine catabolic process

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.