Overview
| Uniprot ID | Q8R081 |
|---|
| Protein Name | Heterogeneous nuclear ribonucleoprotein L |
|---|
| Gene Name | Hnrnpl |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 62 |
GRAPKRLKTENAGDQ |
Function
Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion (PubMed:22523384). Exhibits a binding preference for CA-rich elements. Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts. Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (By similarity). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8
Protein Sequence
10
MSRRLLPRAE
20
KRRRRLEQRQ
30
QPDEQLRRAG
40
AMVKMAAAGG
50
GGGGGRYYGG
60
GNEGGRAPKR
70
LKTENAGDQH
80
GGGGGGGSGA
90
AGGGGGENYD
100
DPHKTPASPV
110
VHIRGLIDGV
120
VEADLVEALQ
130
EFGPISYVVV
140
MPKKRQALVE
150
FEDVLGACNA
160
VNYAADNQIY
170
IAGHPAFVNY
180
STSQKISRPG
190
DSDDSRSVNS
200
VLLFTILNPI
210
YSITTDVLYT
220
ICNPCGPVQR
230
IVIFRKNGVQ
240
AMVEFDSVQS
250
AQRAKASLNG
260
ADIYSGCCTL
270
KIEYAKPTRL
280
NVFKNDQDTW
290
DYTNPNLSGQ
300
GDPGSNPNKR
310
QRQPPLLGDH
320
PAEYGGPHGG
330
YHSHYHDEGY
340
GPPPPHYEGR
350
RMGPPVGGHR
360
RGPSRYGPQY
370
GHPPPPPPPP
380
DYGPHADSPV
390
LMVYGLDQSK
400
MNCDRVFNVF
410
CLYGNVEKVK
420
FMKSKPGAAM
430
VEMADGYAVD
440
RAITHLNNNF
450
MFGQKMNVCV
460
SKQPAIMPGQ
470
SYGLEDGSCS
480
YKDFSESRNN
490
RFSTPEQAAK
500
NRIQHPSNVL
510
HFFNAPLEVT
520
EENFFEICDE
530
LGVKRPTSVK
540
VFSGKSERSS
550
SGLLEWDSKS
560
DALETLGFLN
570
HYQMKNPNGP
580
YPYTLKLCFS
TAQHAS
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0045202 |
synapse |
| Cellular Component |
GO:0000785 |
chromatin |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005654 |
nucleoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0048471 |
perinuclear region of cytoplasm |
| Cellular Component |
GO:0045120 |
pronucleus |
| Cellular Component |
GO:1990904 |
ribonucleoprotein complex |
| Cellular Component |
GO:0035770 |
ribonucleoprotein granule |
| Molecular Function |
GO:0003730 |
mRNA 3'-UTR binding |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Molecular Function |
GO:1990715 |
mRNA CDS binding |
| Molecular Function |
GO:0097157 |
pre-mRNA intronic binding |
| Molecular Function |
GO:0003723 |
RNA binding |
| Molecular Function |
GO:0000976 |
transcription cis-regulatory region binding |
| Biological Process |
GO:0034198 |
cellular response to amino acid starvation |
| Biological Process |
GO:0006397 |
mRNA processing |
| Biological Process |
GO:0045892 |
negative regulation of DNA-templated transcription |
| Biological Process |
GO:0048025 |
negative regulation of mRNA splicing, via spliceosome |
| Biological Process |
GO:0045727 |
positive regulation of translation |
| Biological Process |
GO:0000381 |
regulation of alternative mRNA splicing, via spliceosome |
| Biological Process |
GO:0043484 |
regulation of RNA splicing |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.