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Overview

Uniprot IDQ8R0Y8
Protein NameMitochondrial coenzyme A transporter SLC25A42
Gene NameSlc25a42
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
66 IIFQVSSKRFSAKEA

Function

Mitochondrial carrier mediating the transport of coenzyme A (CoA) in mitochondria in exchange for intramitochondrial (deoxy)adenine nucleotides and adenosine 3',5'-diphosphate

Protein Sequence

10 MGNGVQEGSV 20 RLREDAEAVL 30 AGAVSSKRDH 40 RQVLSSLLSG 50 ALAGALAKTA 60 VAPLDRTKII 70 FQVSSKRFSA 80 KEAFRLLYFT 90 YLNEGFLSLW 100 RGNSATMVRV 110 IPYAAIQFSA 120 HEEYKRILGH 130 YYGFRGEALP 140 PWPRLLAGAL 150 AGTTAASLTY 160 PLDLVRARMA 170 VTPKEMYSNI 180 FHVFIRISRE 190 EGLKTLYFGF 200 TPTVLGVIPY 210 AGLSFFTYES 220 LKSLHREYSG 230 RPQPYPFERM 240 VFGACAGLIG 250 QSASYPLDVV 260 RRRMQTAGVT 270 GHQHGSILST 280 LRSIVREEGA 290 VRGLYKGLSM 300 NWLKGPIAVG 310 ISFTTFDLMQ ILLRRLQS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0043262 ADP phosphatase activity
Molecular Function GO:0015217 ADP transmembrane transporter activity
Molecular Function GO:0080122 AMP transmembrane transporter activity
Molecular Function GO:0005347 ATP transmembrane transporter activity
Molecular Function GO:0015228 coenzyme A transmembrane transporter activity
Molecular Function GO:0015291 secondary active transmembrane transporter activity
Biological Process GO:0015866 ADP transport
Biological Process GO:0080121 AMP transport
Biological Process GO:0015867 ATP transport
Biological Process GO:0015937 coenzyme A biosynthetic process
Biological Process GO:0035349 coenzyme A transmembrane transport
Biological Process GO:1990559 mitochondrial coenzyme A transmembrane transport

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.