Search Results

Overview

Uniprot ID	Q8R164
Protein Name	Serine hydrolase BPHL
Gene Name	Bphl
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
191	KWSEKARKPLEALYG
271	LHLMPEGKHNLHLRF

Function

Specific alpha-amino acid ester serine hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. Has homocysteine-thiolactonase activity (in vitro) and may play a significant role in the detoxification of homocysteine thiolactone in vivo. Catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir, converting them into their active forms (acyclovir and ganciclovir)

Protein Sequence

10 MATATVRPAA 20 QRLRLLLSPL 30 KSRICVPQAE 40 PVATFGTAVT 50 SAKVAVNGVH 60 LHYQRVGEGE 70 HAILLLPGML 80 GSGKTDFAPQ 90 LQSLNKKRFT 100 LVAWDPRGYG 110 YSRPPDRDFP 120 RDFFERDAKD 130 AVDLMKALQF 140 KQVSLLGWSD 150 GGITALIAAA 160 KYPSYIRKMV 170 IWGANAYVTE 180 EDSRIYQGIR 190 DVSKWSEKAR 200 KPLEALYGYD 210 YLAKTCEDWV 220 DGISQFKQLP 230 EGNICRHLLP 240 LVQCPTLIVH 250 GEKDPLVPRF 260 HADFLLQHVK 270 GSRLHLMPEG 280 KHNLHLRFAD 290 EFNRLVEDFL Q

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0047658	alpha-amino-acid esterase activity
Molecular Function	GO:0046872	metal ion binding
Molecular Function	GO:0017171	serine hydrolase activity
Biological Process	GO:0050667	homocysteine metabolic process
Biological Process	GO:0006805	xenobiotic metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.