Search Results
Overview
| Uniprot ID | Q8R1G2 |
|---|---|
| Protein Name | Carboxymethylenebutenolidase homolog |
| Gene Name | Cmbl |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 227 | EDCSPADKPYIEEAR |
Function
Cysteine hydrolase whose endogenous substrates and physiological function are unknown. In vitro, catalyzes the hydrolytic activation of several ester-based prodrugs, by cleaving the dioxolone ring to yield their respective active metabolites, diacetyl and CO2
Protein Sequence
10
MANEANPCPC
20
DIGHKLEYGG
30
MGHEVQVEHI
40
KAYVTRSPVD
50
AGKAVIVVQD
60
IFGWQLPNTR
70
YMADMIARNG
80
YTTIVPDFFV
90
GQEPWDPAGD
100
WSTFPAWLKS
110
RNARKVNREV
120
DAVLRYLRQQ
130
CHAQKIGIVG
140
FCWGGVVVHQ
150
VMTAYPDIRA
160
GVSVYGIIRD
170
SEDVYNLKNP
180
TLFIFAENDT
190
VIPLEQVSTL
200
TQKLKEHCIV
210
NYQVKTFSGQ
220
THGFVHRKRE
230
DCSPADKPYI
240
EEARRNLIEW
LNKYV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Molecular Function | GO:0016787 | hydrolase activity |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.