Search Results
Overview
| Uniprot ID | Q8R2Q0 |
|---|---|
| Protein Name | Tripartite motif-containing protein 29 |
| Gene Name | Trim29 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 300 | QKEKDRIKSFTTNEK |
Function
Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of pro-inflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation
Protein Sequence
10
MEGADACRSN
20
GASPEARDTR
30
SPPGPSGSLE
40
NGTKADSKDT
50
KTTNGHSGEV
60
TEGKTLGSAL
70
KSGEGKSGLF
80
SSNEWRRPII
90
QFVESVDDKG
100
SSYFSMDSAE
110
GRRSPYAGLQ
120
LGASKKPPVT
130
FAEKGELRKS
140
IFSEPRKPTV
150
TIVEPGEVRR
160
NSYPRADSSL
170
LARAKSGSEE
180
VLCDSCIGNK
190
QKAVKSCLVC
200
QASFCELHLK
210
PHLEGAAFRD
220
HQLLEPIRDF
230
EARKCPLHGK
240
TMELFCQTDQ
250
TCICYLCMFQ
260
EHKNHSTVTV
270
EEAKAEKETE
280
LSLQKEQLQL
290
KIIEIEDDVE
300
KWQKEKDRIK
310
SFTTNEKAIL
320
EQNFRDLVRE
330
LEKQKEEVRA
340
ALEQREQDAV
350
DQVKVIVDAL
360
DERAKVLHED
370
KQTREQLHNI
380
SDSVLFLQEF
390
GALMSNYSLP
400
PPLPTYHVLL
410
EGEGLGQSLG
420
NCKDDLLNVC
430
MRHVEKMCKA
440
DLSRNFIERN
450
HMENGGDHRY
460
MNSYTSSYGN
470
EWSTPDTMKR
480
YSMYLTPKGG
490
GRTSYQPSSP
500
SRLSKETNQK
510
NFNNLYGTKG
520
NYTSRVWEYT
530
STVQNSEDMP
540
TVQGNSSFSL
550
KGFPSLLRSQ
560
VPKAQPQTWK
570
SGKQTLLSHY
580
RPFYVNKGSG
IGSNEAP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005764 | lysosome |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0002039 | p53 binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0045087 | innate immune response |
| Biological Process | GO:1900181 | negative regulation of protein localization to nucleus |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.