Search Results

Overview

Uniprot ID	Q8R2Q4
Protein Name	Ribosome-releasing factor 2, mitochondrial
Gene Name	Gfm2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
271	ASDRELLKETIEARN

Function

Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Acts in collaboration with MRRF. GTP hydrolysis follows the ribosome disassembly and probably occurs on the ribosome large subunit. Not involved in the GTP-dependent ribosomal translocation step during translation elongation

Protein Sequence

10 MFTKWRIFAV 20 NHQRTFSVHL 30 NTMCYCKIKA 40 NLKRLKTQLP 50 LTRNYSSAPG 60 IAGSDVKSLH 70 SVINPPVAKI 80 RNIGIMAHID 90 AGKTTTTERI 100 LYYSGYTRSL 110 GDVDDGDTVT 120 DFMAQERERG 130 ITIQSAAVTL 140 DWKGYRVNLI 150 DTPGHVDFTL 160 EVERCLRVLD 170 GAVAVFDASA 180 GVEAQTLTVW 190 RQADKHKIPR 200 ICFLNKMDKT 210 GASFNYAVES 220 IREKLKAKPL 230 ILQLPIGEAR 240 TFQGVVDVVN 250 KEKLLWNSNS 260 DDGKDFERMP 270 LSEASDRELL 280 KETIEARNSL 290 IEQVADLDDE 300 FADLVLGEFS 310 ENFDLVPAEK 320 LQAAVHRVTL 330 AQAAVPVLCG 340 SALKNKGVQP 350 LLDAVTTYLP 360 SPEEREDRFL 370 QWYEGDLCAL 380 AFKVLHDKQR 390 GPLVFLRIYS 400 GTLTPQLAVH 410 NINRNCTERM 420 SRLLLPFADQ 430 HVEIPSLTAG 440 NIALTVGLKQ 450 TATGDTIVSS 460 KSSALAAARR 470 AGRGEREHGK 480 KREAESLLLA 490 GVEVPEPVFF 500 CTIEPPSVAK 510 QPDLDHALER 520 LQREDPSLKV 530 KLDPDSGQTV 540 LCGMGELHIE 550 IIHDRIKREY 560 GLETYLGPLQ 570 VAYRETILNS 580 VRATDTLDRV 590 LGDKRHLVSA 600 ELEVRPAEEP 610 CAVAKIEYAD 620 CVGEDLLQAS 630 REAIESAVHS 640 ACLQGPLLGS 650 PVQDVAMTLH 660 SLMIHPGTST 670 TMVTACISRC 680 MQKALKKADK 690 QVLEPLMSLE 700 VTVSREYLSP 710 VLADLAQRRG 720 NIQEIQTRQD 730 NRVVLGFVPL 740 AEIMGYSTVL 750 RTLTSGSATF 760 ALELSTYQAM 770 SPQDQSALLN QRSGLAHVL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005525	GTP binding
Molecular Function	GO:0003924	GTPase activity
Biological Process	GO:0032543	mitochondrial translation
Biological Process	GO:0032790	ribosome disassembly

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.