Search Results
Overview
| Uniprot ID | Q8R429 |
|---|---|
| Protein Name | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 |
| Gene Name | Atp2a1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 128 | EYEPEMGKVYRADRK |
| 169 | DIRILSIKSTTLRVD |
| 205 | RAVNQDKKNMLFSGT |
| 246 | MAATEQDKTPLQQKL |
| 35 | QVKRHLEKYGPNELP |
| 481 | VIRQLMKKEFTLEFS |
| 502 | SVYCSPAKSSRAAVG |
| 515 | VGNKMFVKGAPEGVI |
| 542 | VPLTGPVKEKIMSVI |
| 550 | EKIMSVIKEWGTGRD |
| 605 | GMLDPPRKEVTGSIQ |
| 629 | IMITGDNKGTAIAIC |
| 713 | NDAPALKKAEIGIAM |
Function
Key regulator of striated muscle performance by acting as the major Ca(2+) ATPase responsible for the reuptake of cytosolic Ca(2+) into the sarcoplasmic reticulum (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378, PubMed:27923914). Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction (PubMed:21697544, PubMed:22961106, PubMed:25640239, PubMed:26816378)
Protein Sequence
10
MEAAHSKSTE
20
ECLSYFGVSE
30
TTGLTPDQVK
40
RHLEKYGPNE
50
LPAEEGKSLW
60
ELVVEQFEDL
70
LVRILLLAAC
80
ISFVLAWFEE
90
GEETVTAFVE
100
PFVILLILIA
110
NAIVGVWQER
120
NAENAIEALK
130
EYEPEMGKVY
140
RADRKSVQRI
150
KARDIVPGDI
160
VEVAVGDKVP
170
ADIRILSIKS
180
TTLRVDQSIL
190
TGESVSVIKH
200
TDPVPDPRAV
210
NQDKKNMLFS
220
GTNIAAGKAV
230
GIVATTGVST
240
EIGKIRDQMA
250
ATEQDKTPLQ
260
QKLDEFGEQL
270
SKVISLICVA
280
VWLINIGHFN
290
DPVHGGSWFR
300
GAIYYFKIAV
310
ALAVAAIPEG
320
LPAVITTCLA
330
LGTRRMAKKN
340
AIVRSLPSVE
350
TLGCTSVICS
360
DKTGTLTTNQ
370
MSVCKMFIID
380
KVDGDVCSLN
390
EFSITGSTYA
400
PEGEVLKNDK
410
PVRAGQYDGL
420
VELATICALC
430
NDSSLDFNET
440
KGVYEKVGEA
450
TETALTTLVE
460
KMNVFNTEVR
470
SLSKVERANA
480
CNSVIRQLMK
490
KEFTLEFSRD
500
RKSMSVYCSP
510
AKSSRAAVGN
520
KMFVKGAPEG
530
VIDRCNYVRV
540
GTTRVPLTGP
550
VKEKIMSVIK
560
EWGTGRDTLR
570
CLALATRDTP
580
PKREEMVLDD
590
SAKFMEYEMD
600
LTFVGVVGML
610
DPPRKEVTGS
620
IQLCRDAGIR
630
VIMITGDNKG
640
TAIAICRRIG
650
IFSENEEVTD
660
RAYTGREFDD
670
LPLAEQREAC
680
RRACCFARVE
690
PSHKSKIVEY
700
LQSYDEITAM
710
TGDGVNDAPA
720
LKKAEIGIAM
730
GSGTAVAKTA
740
SEMVLADDNF
750
STIVAAVEEG
760
RAIYNNMKQF
770
IRYLISSNVG
780
EVVCIFLTAA
790
LGLPEALIPV
800
QLLWVNLVTD
810
GLPATALGFN
820
PPDLDIMDRP
830
PRSPKEPLIS
840
GWLFFRYMAI
850
GGYVGAATVG
860
AAAWWFLYAE
870
DGPHVSYHQL
880
THFMQCTEHN
890
PEFDGLDCEV
900
FEAPEPMTMA
910
LSVLVTIEMC
920
NALNSLSENQ
930
SLLRMPPWVN
940
IWLLGSICLS
950
MSLHFLILYV
960
DPLPMIFKLR
970
ALDFTQWLMV
980
LKISLPVIGL
990
DELLKFIARN
YLEG
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005783 | endoplasmic reticulum |
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment |
| Cellular Component | GO:0031673 | H zone |
| Cellular Component | GO:0031674 | I band |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0016529 | sarcoplasmic reticulum |
| Cellular Component | GO:0033017 | sarcoplasmic reticulum membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0016887 | ATP hydrolysis activity |
| Molecular Function | GO:0005509 | calcium ion binding |
| Molecular Function | GO:0030899 | calcium-dependent ATPase activity |
| Molecular Function | GO:0005338 | nucleotide-sugar transmembrane transporter activity |
| Molecular Function | GO:0005388 | P-type calcium transporter activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Biological Process | GO:0008637 | apoptotic mitochondrial changes |
| Biological Process | GO:0070509 | calcium ion import |
| Biological Process | GO:1990036 | calcium ion import into sarcoplasmic reticulum |
| Biological Process | GO:0070588 | calcium ion transmembrane transport |
| Biological Process | GO:0006816 | calcium ion transport |
| Biological Process | GO:0006874 | intracellular calcium ion homeostasis |
| Biological Process | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| Biological Process | GO:0051659 | maintenance of mitochondrion location |
| Biological Process | GO:0032471 | negative regulation of endoplasmic reticulum calcium ion concentration |
| Biological Process | GO:0045988 | negative regulation of striated muscle contraction |
| Biological Process | GO:1901896 | positive regulation of ATPase-coupled calcium transmembrane transporter activity |
| Biological Process | GO:1902082 | positive regulation of calcium ion import into sarcoplasmic reticulum |
| Biological Process | GO:0106134 | positive regulation of cardiac muscle cell contraction |
| Biological Process | GO:0032470 | positive regulation of endoplasmic reticulum calcium ion concentration |
| Biological Process | GO:0031448 | positive regulation of fast-twitch skeletal muscle fiber contraction |
| Biological Process | GO:0051561 | positive regulation of mitochondrial calcium ion concentration |
| Biological Process | GO:0006937 | regulation of muscle contraction |
| Biological Process | GO:0006942 | regulation of striated muscle contraction |
| Biological Process | GO:0090076 | relaxation of skeletal muscle |
| Biological Process | GO:0034976 | response to endoplasmic reticulum stress |
| Biological Process | GO:0043434 | response to peptide hormone |
| Biological Process | GO:0070296 | sarcoplasmic reticulum calcium ion transport |
Reference
[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.