Search Results
Overview
| Uniprot ID | Q8SQ23 |
|---|---|
| Protein Name | Tissue-type plasminogen activator |
| Gene Name | PLAT |
| Organism | Sus scrofa |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 212 | TPACTKEKEECYTGK |
Function
Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. During oocyte activation, plays a role in cortical granule reaction in the zona reaction, which contributes to the block to polyspermy
Protein Sequence
10
MYALKRELWC
20
VLLLCGAICT
30
SPSQETHRRL
40
RRGVRSYRVT
50
CRDEKTQMIY
60
QQHQSWLRPL
70
LRGNRVEHCW
80
CNDGQTQCHS
90
VPVKSCSEPR
100
CFNGGTCLQA
110
IYFSDFVCQC
120
PVGFIGRQCE
130
IDARATCYED
140
QGITYRGTWS
150
TTESGAECVN
160
WNTSGLASMP
170
YNGRRPDAVK
180
LGLGNHNYCR
190
NPDKDSKPWC
200
YIFKAEKYSP
210
DFCSTPACTK
220
EKEECYTGKG
230
LDYRGTRSLT
240
MSGAFCLPWN
250
SLVLMGKIYT
260
AWNSNAQTLG
270
LGKHNYCRNP
280
DGDTQPWCHV
290
LKDHKLTWEY
300
CDLPQCVTCG
310
LRQYKEPQFR
320
IKGGLYADIT
330
SHPWQAAIFV
340
KNRRSPGERF
350
LCGGILISSC
360
WVLSAAHCFQ
370
ERFPPHHVRV
380
VLGRTYRLVP
390
GEEEQAFEVE
400
KYIVHKEFDD
410
DTYDNDIALL
420
QLKSDSLTCA
430
QESDAVRTVC
440
LPEANLQLPD
450
WTECELSGYG
460
KHEASSPFYS
470
ERLKEAHVRL
480
YPSSRCTSKH
490
LFNKTITNNM
500
LCAGDTRSGG
510
DNANLHDACQ
520
GDSGGPLVCM
530
KGNHMTLVGV
540
ISWGLGCGQK
550
DVPGVYTKVT
560
NYLNWIRDNT
RP
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005615 | extracellular space |
| Molecular Function | GO:0004252 | serine-type endopeptidase activity |
| Biological Process | GO:0031639 | plasminogen activation |
| Biological Process | GO:0048008 | platelet-derived growth factor receptor signaling pathway |
| Biological Process | GO:0060468 | prevention of polyspermy |
| Biological Process | GO:0014909 | smooth muscle cell migration |
Reference
[1] Fan S, Zhou R, Wen H, Ye H, Ma S et al.. Global profiling of protein lactylome in porcine granulosa cells.. J Ovarian Res 18(1):177. 2025 Aug 8. PMID: 40781717.