Overview
| Uniprot ID | Q8TAA3 |
|---|
| Protein Name | Proteasome subunit alpha-type 8 |
|---|
| Gene Name | PSMA8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 49 |
IVVLGVEKKSVAKLQ |
| 50 |
VVLGVEKKSVAKLQD |
| 54 |
VEKKSVAKLQDERTV |
Function
Component of the spermatoproteasome, a proteasome specifically found in testis that promotes acetylation-dependent degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. The proteasome is a protein complex that degrades unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Required for 20S core proteasome assembly, essential for the degradation of meiotic proteins RAD51 and RPA1 at late prophase I and the progression of meiosis I during spermatogenesis. Localizes to the synaptonemal complex, a 'zipper'-like structure that holds homologous chromosome pairs in synapsis during meiotic prophase I
Protein Sequence
10
MASRYDRAIT
20
VFSPDGHLFQ
30
VEYAQEAVKK
40
GSTAVGIRGT
50
NIVVLGVEKK
60
SVAKLQDERT
70
VRKICALDDH
80
VCMAFAVLTI
90
FIGLTADARV
100
VINRARVECQ
110
SHKLTVEDPV
120
TVEYITRFIA
130
TLKQKYTQSN
140
GRRPFGISAL
150
IVGFDDDGIS
160
RLYQTDPSGT
170
YHAWKANAIG
180
RSAKTVREFL
190
EKNYTEDAIA
200
SDSEAIKLAI
210
KALLEVVQSG
220
GKNIELAIIR
230
RNQPLKMFSA
240
KEVELYVTEI
250
EKEKEEAEKK
KSKKSV
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0019773 |
proteasome core complex, alpha-subunit complex |
| Cellular Component |
GO:1990111 |
spermatoproteasome complex |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0030317 |
flagellated sperm motility |
| Biological Process |
GO:0051321 |
meiotic cell cycle |
| Biological Process |
GO:0010498 |
proteasomal protein catabolic process |
| Biological Process |
GO:0043161 |
proteasome-mediated ubiquitin-dependent protein catabolic process |
| Biological Process |
GO:0060631 |
regulation of meiosis I |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.