Search Results
Overview
| Uniprot ID | Q8TAM6 |
|---|---|
| Protein Name | Ermin |
| Gene Name | ERMN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 174 | QADMLHSKHDEEQKV |
| 209 | RVIEFKKKHEEVSQF |
| 55 | SLEGALTKGSQEERR |
Function
Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS (By similarity)
Protein Sequence
10
MTDVPATFTQ
20
AECNGDKPPE
30
NGQQTITKIS
40
EELTDVDSPL
50
PHYRVEPSLE
60
GALTKGSQEE
70
RRKLQGNMLL
80
NSSMEDKMLK
90
ENPEEKLFIV
100
HKAITDLSLQ
110
ETSADEMTFR
120
EGHQWEKIPL
130
SGSNQEIRRQ
140
KERITEQPLK
150
EEEDEDRKNK
160
GHQAAEIEWL
170
GFRKPSQADM
180
LHSKHDEEQK
190
VWDEEIDDDD
200
DDNCNNDEDE
210
VRVIEFKKKH
220
EEVSQFKEEG
230
DASEDSPLSS
240
ASSQAVTPDE
250
QPTLGKKSDI
260
SRNAYSRYNT
270
ISYRKIRKGN
280
TKQRIDEFES
MMHL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0070062 | extracellular exosome |
| Cellular Component | GO:0030175 | filopodium |
| Cellular Component | GO:0033269 | internode region of axon |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0043025 | neuronal cell body |
| Cellular Component | GO:0033270 | paranode region of axon |
| Molecular Function | GO:0051015 | actin filament binding |
| Biological Process | GO:0007015 | actin filament organization |
| Biological Process | GO:0001763 | morphogenesis of a branching structure |
| Biological Process | GO:0031344 | regulation of cell projection organization |
| Biological Process | GO:0008360 | regulation of cell shape |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.