Search Results
Overview
| Uniprot ID | Q8TB37 |
|---|---|
| Protein Name | Iron-sulfur cluster transfer protein NUBPL |
| Gene Name | NUBPL |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 250 | QCPKCKHKTHIFGAD |
Function
Iron-sulfur cluster transfer protein involved in the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) (PubMed:19752196). May deliver one or more Fe-S clusters to complex I subunits (PubMed:19752196)
Protein Sequence
10
MGIWQRLLLF
20
GGVSLRAGGG
30
ATAPLGGSRA
40
MVCGRQLSGA
50
GSETLKQRRT
60
QIMSRGLPKQ
70
KPIEGVKQVI
80
VVASGKGGVG
90
KSTTAVNLAL
100
ALAANDSSKA
110
IGLLDVDVYG
120
PSVPKMMNLK
130
GNPELSQSNL
140
MRPLLNYGIA
150
CMSMGFLVEE
160
SEPVVWRGLM
170
VMSAIEKLLR
180
QVDWGQLDYL
190
VVDMPPGTGD
200
VQLSVSQNIP
210
ITGAVIVSTP
220
QDIALMDAHK
230
GAEMFRRVHV
240
PVLGLVQNMS
250
VFQCPKCKHK
260
THIFGADGAR
270
KLAQTLGLEV
280
LGDIPLHLNI
290
REASDTGQPI
300
VFSQPESDEA
310
KAYLRIAVEV
VRRLPSPSE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0051539 | 4 iron, 4 sulfur cluster binding |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140663 | ATP-dependent FeS chaperone activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0016226 | iron-sulfur cluster assembly |
| Biological Process | GO:0032981 | mitochondrial respiratory chain complex I assembly |
| Biological Process | GO:0007005 | mitochondrion organization |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.