Search Results
Overview
| Uniprot ID | Q8TB61 |
|---|---|
| Protein Name | Adenosine 3'-phospho 5'-phosphosulfate transporter 1 |
| Gene Name | SLC35B2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 216 | FPTQVLAKASKVIPV |
Function
Probably functions as a 3'-phosphoadenylyl sulfate:adenosine 3',5'-bisphosphate antiporter at the Golgi membranes. Mediates the transport from the cytosol into the lumen of the Golgi of 3'-phosphoadenylyl sulfate/adenosine 3'-phospho 5'-phosphosulfate (PAPS), a universal sulfuryl donor for sulfation events that take place in that compartment
Protein Sequence
10
MDARWWAVVV
20
LAAFPSLGAG
30
GETPEAPPES
40
WTQLWFFRFV
50
VNAAGYASFM
60
VPGYLLVQYF
70
RRKNYLETGR
80
GLCFPLVKAC
90
VFGNEPKASD
100
EVPLAPRTEA
110
AETTPMWQAL
120
KLLFCATGLQ
130
VSYLTWGVLQ
140
ERVMTRSYGA
150
TATSPGERFT
160
DSQFLVLMNR
170
VLALIVAGLS
180
CVLCKQPRHG
190
APMYRYSFAS
200
LSNVLSSWCQ
210
YEALKFVSFP
220
TQVLAKASKV
230
IPVMLMGKLV
240
SRRSYEHWEY
250
LTATLISIGV
260
SMFLLSSGPE
270
PRSSPATTLS
280
GLILLAGYIA
290
FDSFTSNWQD
300
ALFAYKMSSV
310
QMMFGVNFFS
320
CLFTVGSLLE
330
QGALLEGTRF
340
MGRHSEFAAH
350
ALLLSICSAC
360
GQLFIFYTIG
370
QFGAAVFTII
380
MTLRQAFAIL
390
LSCLLYGHTV
400
TVVGGLGVAV
410
VFAALLLRVY
420
ARGRLKQRGK
430
KAVPVESPVQ
KV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Cellular Component | GO:0005794 | Golgi apparatus |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0005802 | trans-Golgi network |
| Molecular Function | GO:0046964 | 3'-phosphoadenosine 5'-phosphosulfate transmembrane transporter activity |
| Molecular Function | GO:0015297 | antiporter activity |
| Biological Process | GO:0046963 | 3'-phosphoadenosine 5'-phosphosulfate transport |
| Biological Process | GO:1902558 | 5'-adenylyl sulfate transmembrane transport |
| Biological Process | GO:0050650 | chondroitin sulfate proteoglycan biosynthetic process |
| Biological Process | GO:0043123 | positive regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0055085 | transmembrane transport |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.