Search Results
Overview
| Uniprot ID | Q8TBE0 |
|---|---|
| Protein Name | Bromo adjacent homology domain-containing 1 protein |
| Gene Name | BAHD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 71 | PEKPKACKVLLTRLE |
Function
Heterochromatin protein that acts as a transcription repressor and has the ability to promote the formation of large heterochromatic domains. May act by recruiting heterochromatin proteins such as CBX5 (HP1 alpha), HDAC5 and MBD1. Represses IGF2 expression by binding to its CpG-rich P3 promoter and recruiting heterochromatin proteins. At specific stages of Listeria infection, in complex with TRIM28, corepresses interferon-stimulated genes, including IFNL1, IFNL2 and IFNL3
Protein Sequence
10
MTHTRRKSLP
20
MLSSGLTGRR
30
EPLQMEDSNM
40
EQGVEGVEPG
50
MPESPGHLTG
60
RRKNYPLRKR
70
PLVPEKPKAC
80
KVLLTRLENV
90
AGPRSADEAD
100
ELPPDLPKPP
110
SPAPSSEDPG
120
LAQPRKRRLA
130
SLNAEALNNL
140
LLEREDTSSL
150
AGTRRSRAGD
160
PHRSRDRDRA
170
TGGWSSSKKR
180
PRLGDLGGGS
190
RDLSPEPAPD
200
EGPRRDGDPA
210
PKRLASLNAA
220
AFLKLSQERE
230
LPLRLPRAHA
240
EVDGRSTEPP
250
APKAPRPKWP
260
KVNGKNYPKA
270
WQGASSGEAA
280
GPPGWQGCPD
290
EPWPSATPCG
300
PSVQPSHQPL
310
SKALESPLGL
320
RPHLPLLMGG
330
QAALKPEPGR
340
PGEESPAPKQ
350
ELHQPSFPTP
360
QLSPLPMPGN
370
PADYNGLCVG
380
PELTALGSFY
390
LYCGQEGLQC
400
GGYSPCPMLP
410
EGKLSPVAAP
420
HEEGLLLAPS
430
SVPSGTPFQH
440
PPWGSSRYCS
450
SEDTGVNGYS
460
ICGVLPLSVT
470
HAGTTCGGCP
480
YKMPFAAEGC
490
RSLGQLEFPL
500
PEAGHPASPA
510
HPLLGCPVPS
520
VPPAAEPVPH
530
LQTPTSEPQT
540
VARACPQSAK
550
PPSGSKSGLR
560
TGSSCRHTAR
570
SKAARRPSHP
580
KQPRVQRPRP
590
RRRRRRRTNG
600
WVPVGAACEK
610
AVYVLDEPEP
620
AIRKSYQAVE
630
RHGETIRVRD
640
TVLLKSGPRK
650
TSTPYVAKIS
660
ALWENPESGE
670
LMMSLLWYYR
680
PEHLQGGRSP
690
SMHEPLQNEV
700
FASRHQDQNS
710
VACIEEKCYV
720
LTFAEYCRFC
730
AMAKRRGEGL
740
PSRKTALVPP
750
SADYSTPPHR
760
TVPEDTDPEL
770
VFLCRHVYDF
780
RHGRILKNPQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005677 | chromatin silencing complex |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005654 | nucleoplasm |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0000976 | transcription cis-regulatory region binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0031507 | heterochromatin formation |
| Biological Process | GO:0045892 | negative regulation of DNA-templated transcription |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.