Search Results
Overview
| Uniprot ID | Q8TBJ5 |
|---|---|
| Protein Name | Fez family zinc finger protein 2 |
| Gene Name | FEZF2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 264 | GGVKGHSKLPGGSAD |
Function
Transcription repressor. Required for the specification of corticospinal motor neurons and other subcerebral projection neurons. May play a role in layer and neuronal subtype-specific patterning of subcortical projections and axonal fasciculation. Controls the development of dendritic arborization and spines of large layer V pyramidal neurons. May be involved in innate immunity (By similarity)
Protein Sequence
10
MASSASLETM
20
VPPACPRAGA
30
SPATSKTLAF
40
SIERIMAKTS
50
EPRAPFEPRP
60
GALEADGSQG
70
KKLLNLCSPL
80
PCMIPLQPLG
90
YEVPSKTLLS
100
YSELWKSSLR
110
AGGGGGGGGG
120
GGGGGGGAPV
130
CGASGLCKTN
140
CGVCCKAELG
150
LAPSALPAGR
160
VIKPQVINQA
170
VGLPASGSLY
180
YFNYLDSTAY
190
PPSELLSGHL
200
FPSGLLNAQA
210
PAALAAHPKL
220
FLLENAKLAG
230
LAADKFPHPA
240
PYPHKERLPA
250
PLEQVLKENS
260
ALTAERGGVK
270
GHSKLPGGSA
280
DGKPKNFTCE
290
VCGKVFNAHY
300
NLTRHMPVHT
310
GARPFVCKVC
320
GKGFRQASTL
330
CRHKIIHTQE
340
KPHKCNQCGK
350
AFNRSSTLNT
360
HIRIHAGYKP
370
FVCEFCGKGF
380
HQKGNYKNHK
390
LTHSGEKQYK
400
CTICNKAFHQ
410
VYNLTFHMHT
420
HNDKKPFTCA
430
TCGKGFCRNF
440
DLKKHVRKLH
450
DSVGPAAPSA
KDLTRTVQS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0001227 | DNA-binding transcription repressor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0043697 | cell dedifferentiation |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0010468 | regulation of gene expression |
| Biological Process | GO:0050767 | regulation of neurogenesis |
| Biological Process | GO:0021537 | telencephalon development |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.