Search Results

Overview

Uniprot IDQ8TBX8
Protein NamePhosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Gene NamePIP4K2C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
260 YIGEEEKKIFLEKLK
37 KKHFVQQKVKVFRAA
393 AHAAKTVKHGAGAEI

Function

Phosphatidylinositol 5-phosphate 4-kinase with low enzymatic activity. May be a GTP sensor, has higher GTP-dependent kinase activity than ATP-dependent kinase activity. PIP4Ks negatively regulate insulin signaling through a catalytic-independent mechanism. They interact with PIP5Ks and suppress PIP5K-mediated PtdIns(4,5)P2 synthesis and insulin-dependent conversion to PtdIns(3,4,5)P3 (PubMed:31091439)

Protein Sequence

10 MASSSVPPAT 20 VSAATAGPGP 30 GFGFASKTKK 40 KHFVQQKVKV 50 FRAADPLVGV 60 FLWGVAHSIN 70 ELSQVPPPVM 80 LLPDDFKASS 90 KIKVNNHLFH 100 RENLPSHFKF 110 KEYCPQVFRN 120 LRDRFGIDDQ 130 DYLVSLTRNP 140 PSESEGSDGR 150 FLISYDRTLV 160 IKEVSSEDIA 170 DMHSNLSNYH 180 QYIVKCHGNT 190 LLPQFLGMYR 200 VSVDNEDSYM 210 LVMRNMFSHR 220 LPVHRKYDLK 230 GSLVSREASD 240 KEKVKELPTL 250 KDMDFLNKNQ 260 KVYIGEEEKK 270 IFLEKLKRDV 280 EFLVQLKIMD 290 YSLLLGIHDI 300 IRGSEPEEEA 310 PVREDESEVD 320 GDCSLTGPPA 330 LVGSYGTSPE 340 GIGGYIHSHR 350 PLGPGEFESF 360 IDVYAIRSAE 370 GAPQKEVYFM 380 GLIDILTQYD 390 AKKKAAHAAK 400 TVKHGAGAEI 410 STVHPEQYAK 420 RFLDFITNIF A

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005776 autophagosome
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005783 endoplasmic reticulum
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005886 plasma membrane
Molecular Function GO:0016308 1-phosphatidylinositol-4-phosphate 5-kinase activity
Molecular Function GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0042802 identical protein binding
Biological Process GO:1902635 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process
Biological Process GO:0046627 negative regulation of insulin receptor signaling pathway
Biological Process GO:0046854 phosphatidylinositol phosphate biosynthetic process
Biological Process GO:2000786 positive regulation of autophagosome assembly
Biological Process GO:0010506 regulation of autophagy

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.