Overview
| Uniprot ID | Q8TBY0 |
|---|
| Protein Name | Probable RNA-binding protein 46 |
|---|
| Gene Name | RBM46 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 153 |
GAIPKEKKKEEILDE |
| 154 |
AIPKEKKKEEILDEM |
Function
Essential for male and female fertility, playing a crucial role in regulating germ cell development by ensuring the proper progression of meiosis prophase I (By similarity). Regulates mitotic-to-meiotic transition in spermatogenesis by forming a complex with MEIOC and YTHDC2 which recognizes and down-regulates mitotic transcripts for a successful meiotic entry (By similarity). Required for normal synaptonemal complex formation during meiosis, binding meiotic cohesin subunit mRNAs containing GCCUAU/GUUCGA motifs in their 3'UTRs regions and positively regulating their translation (By similarity). Required for spermatogonial differentiation in both developing and adult testis (By similarity)
Protein Sequence
10
MNEENIDGTN
20
GCSKVRTGIQ
30
NEAALLALME
40
KTGYNMVQEN
50
GQRKFGGPPP
60
GWEGPPPPRG
70
CEVFVGKIPR
80
DMYEDELVPV
90
FERAGKIYEF
100
RLMMEFSGEN
110
RGYAFVMYTT
120
KEEAQLAIRI
130
LNNYEIRPGK
140
FIGVCVSLDN
150
CRLFIGAIPK
160
EKKKEEILDE
170
MKKVTEGVVD
180
VIVYPSATDK
190
TKNRGFAFVE
200
YESHRAAAMA
210
RRKLIPGTFQ
220
LWGHTIQVDW
230
ADPEKEVDEE
240
TMQRVKVLYV
250
RNLMISTTEE
260
TIKAEFNKFK
270
PGAVERVKKL
280
RDYAFVHFFN
290
REDAVAAMSV
300
MNGKCIDGAS
310
IEVTLAKPVN
320
KENTWRQHLN
330
GQISPNSENL
340
IVFANKEESH
350
PKTLGKLPTL
360
PARLNGQHSP
370
SPPEVERCTY
380
PFYPGTKLTP
390
ISMYSLKSNH
400
FNSAVMHLDY
410
YCNKNNWAPP
420
EYYLYSTTSQ
430
DGKVLLVYKI
440
VIPAIANGSQ
450
SYFMPDKLCT
460
TLEDAKELAA
470
QFTLLHLDYN
480
FHRSSINSLS
490
PVSATLSSGT
500
PSVLPYTSRP
510
YSYPGYPLSP
520
TISLANGSHV
530
GQRLCISNQA
SFF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0030895 |
apolipoprotein B mRNA editing enzyme complex |
| Cellular Component |
GO:0005737 |
cytoplasm |
| Cellular Component |
GO:0005634 |
nucleus |
| Molecular Function |
GO:0140767 |
enzyme-substrate adaptor activity |
| Molecular Function |
GO:0003729 |
mRNA binding |
| Biological Process |
GO:0051728 |
cell cycle switching, mitotic to meiotic cell cycle |
| Biological Process |
GO:0007143 |
female meiotic nuclear division |
| Biological Process |
GO:0007140 |
male meiotic nuclear division |
| Biological Process |
GO:1902373 |
negative regulation of mRNA catabolic process |
| Biological Process |
GO:0048477 |
oogenesis |
| Biological Process |
GO:0048515 |
spermatid differentiation |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.