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Overview

Uniprot ID	Q8TC07
Protein Name	TBC1 domain family member 15
Gene Name	TBC1D15
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
68	SSILYARKDSSSVVE

Function

Acts as a GTPase activating protein for RAB7A. Does not act on RAB4, RAB5 or RAB6 (By similarity)

Protein Sequence

10 MAAAGVVSGK 20 IIYEQEGVYI 30 HSSCGKTNDQ 40 DGLISGILRV 50 LEKDAEVIVD 60 WRPLDDALDS 70 SSILYARKDS 80 SSVVEWTQAP 90 KERGHRGSEH 100 LNSYEAEWDM 110 VNTVSFKRKP 120 HTNGDAPSHR 130 NGKSKWSFLF 140 SLTDLKSIKQ 150 NKEGMGWSYL 160 VFCLKDDVVL 170 PALHFHQGDS 180 KLLIESLEKY 190 VVLCESPQDK 200 RTLLVNCQNK 210 SLSQSFENLL 220 DEPAYGLIQA 230 GLLDRRKLLW 240 AIHHWKKIKK 250 DPYTATMIGF 260 SKVTNYIFDS 270 LRGSDPSTHQ 280 RPPSEMADFL 290 SDAIPGLKIN 300 QQEEPGFEVI 310 TRIDLGERPV 320 VQRREPVSLE 330 EWTKNIDSEG 340 RILNVDNMKQ 350 MIFRGGLSHA 360 LRKQAWKFLL 370 GYFPWDSTKE 380 ERTQLQKQKT 390 DEYFRMKLQW 400 KSISQEQEKR 410 NSRLRDYRSL 420 IEKDVNRTDR 430 TNKFYEGQDN 440 PGLILLHDIL 450 MTYCMYDFDL 460 GYVQGMSDLL 470 SPLLYVMENE 480 VDAFWCFASY 490 MDQMHQNFEE 500 QMQGMKTQLI 510 QLSTLLRLLD 520 SGFCSYLESQ 530 DSGYLYFCFR 540 WLLIRFKREF 550 SFLDILRLWE 560 VMWTELPCTN 570 FHLLLCCAIL 580 ESEKQQIMEK 590 HYGFNEILKH 600 INELSMKIDV 610 EDILCKAEAI 620 SLQMVKCKEL 630 PQAVCEILGL 640 QGSEVTTPDS 650 DVGEDENVVM 660 TPCPTSAFQS 670 NALPTLSASG 680 ARNDSPTQIP 690 VSSDVCRLTP A

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005576	extracellular region
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005096	GTPase activator activity
Biological Process	GO:0043087	regulation of GTPase activity

Reference

[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.