Search Results

Overview

Uniprot IDQ8TC12
Protein NameRetinol dehydrogenase 11
Gene NameRDH11
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
112 KSIRAFAKGFLAEEK
59 GIGKETAKELAQRGA

Function

Retinol dehydrogenase with a clear preference for NADP. Displays high activity towards 9-cis, 11-cis and all-trans-retinol, and to a lesser extent on 13-cis-retinol (PubMed:12036956, PubMed:12226107, PubMed:29410696). Exhibits a low reductive activity towards unsaturated medium-chain aldehydes such as cis -6-nonenal and no activity toward nonanal or 4-hydroxy-nonenal (PubMed:15865448). Has no dehydrogenase activity towards steroid (PubMed:12036956, PubMed:12226107)

Protein Sequence

10 MVELMFPLLL 20 LLLPFLLYMA 30 APQIRKMLSS 40 GVCTSTVQLP 50 GKVVVVTGAN 60 TGIGKETAKE 70 LAQRGARVYL 80 ACRDVEKGEL 90 VAKEIQTTTG 100 NQQVLVRKLD 110 LSDTKSIRAF 120 AKGFLAEEKH 130 LHVLINNAGV 140 MMCPYSKTAD 150 GFEMHIGVNH 160 LGHFLLTHLL 170 LEKLKESAPS 180 RIVNVSSLAH 190 HLGRIHFHNL 200 QGEKFYNAGL 210 AYCHSKLANI 220 LFTQELARRL 230 KGSGVTTYSV 240 HPGTVQSELV 250 RHSSFMRWMW 260 WLFSFFIKTP 270 QQGAQTSLHC 280 ALTEGLEILS 290 GNHFSDCHVA 300 WVSAQARNET 310 IARRLWDVSC DLLGLPID

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0001917 photoreceptor inner segment
Molecular Function GO:0102354 11-cis-retinol dehydrogenase (NADP+) activity
Molecular Function GO:0033721 aldehyde dehydrogenase (NADP+) activity
Molecular Function GO:0004745 all-trans-retinol dehydrogenase (NAD+) activity
Molecular Function GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity
Molecular Function GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
Biological Process GO:0110095 cellular detoxification of aldehyde
Biological Process GO:0042574 retinal metabolic process
Biological Process GO:0001523 retinoid metabolic process
Biological Process GO:0042572 retinol metabolic process
Biological Process GO:0007601 visual perception

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.