Search Results

Overview

Uniprot ID	Q8TC27
Protein Name	Disintegrin and metalloproteinase domain-containing protein 32
Gene Name	ADAM32
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
387	QNKPQMQKKSPKPVC
388	NKPQMQKKSPKPVCG

Function

May play a role in sperm development and fertilization This is a non-catalytic metalloprotease-like protein

Protein Sequence

10 MFRLWLLLAG 20 LCGLLASRPG 30 FQNSLLQIVI 40 PEKIQTNTND 50 SSEIEYEQIS 60 YIIPIDEKLY 70 TVHLKQRYFL 80 ADNFMIYLYN 90 QGSMNTYSSD 100 IQTQCYYQGN 110 IEGYPDSMVT 120 LSTCSGLRGI 130 LQFENVSYGI 140 EPLESAVEFQ 150 HVLYKLKNED 160 NDIAIFIDRS 170 LKEQPMDDNI 180 FISEKSEPAV 190 PDLFPLYLEM 200 HIVVDKTLYD 210 YWGSDSMIVT 220 NKVIEIVGLA 230 NSMFTQFKVT 240 IVLSSLELWS 250 DENKISTVGE 260 ADELLQKFLE 270 WKQSYLNLRP 280 HDIAYLLIYM 290 DYPRYLGAVF 300 PGTMCITRYS 310 AGVALYPKEI 320 TLEAFAVIVT 330 QMLALSLGIS 340 YDDPKKCQCS 350 ESTCIMNPEV 360 VQSNGVKTFS 370 SCSLRSFQNF 380 ISNVGVKCLQ 390 NKPQMQKKSP 400 KPVCGNGRLE 410 GNEICDCGTE 420 AQCGPASCCD 430 FRTCVLKDGA 440 KCYKGLCCKD 450 CQILQSGVEC 460 RPKAHPECDI 470 AENCNGTSPE 480 CGPDITLING 490 LSCKNNKFIC 500 YDGDCHDLDA 510 RCESVFGKGS 520 RNAPFACYEE 530 IQSQSDRFGN 540 CGRDRNNKYV 550 FCGWRNLICG 560 RLVCTYPTRK 570 PFHQENGDVI 580 YAFVRDSVCI 590 TVDYKLPRTV 600 PDPLAVKNGS 610 QCDIGRVCVN 620 RECVESRIIK 630 ASAHVCSQQC 640 SGHGVCDSRN 650 KCHCSPGYKP 660 PNCQIRSKGF 670 SIFPEEDMGS 680 IMERASGKTE 690 NTWLLGFLIA 700 LPILIVTTAI 710 VLARKQLKKW 720 FAKEEEFPSS 730 ESKSEGSTQT 740 YASQSSSEGS 750 TQTYASQTRS 760 ESSSQADTSK 770 SKSEDSAEAY 780 TSRSKSQDST QTQSSSN

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0009986	cell surface
Cellular Component	GO:0005886	plasma membrane
Cellular Component	GO:0097228	sperm principal piece
Molecular Function	GO:0004222	metalloendopeptidase activity
Biological Process	GO:0007339	binding of sperm to zona pellucida
Biological Process	GO:0007155	cell adhesion
Biological Process	GO:0008584	male gonad development
Biological Process	GO:0006508	proteolysis

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.