Search Results
Overview
| Uniprot ID | Q8TC29 |
|---|---|
| Protein Name | Enkurin |
| Gene Name | ENKUR |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 133 | VDKRTGDKHDLEPSG |
| 47 | QKAKTAMKTMGPAKV |
Function
Adapter that functions to localize a calcium-sensitive signal transduction machinery in sperm to a calcium-permeable ion channel (By similarity). Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia axoneme, which is required for motile cilia beating (PubMed:36191189)
Protein Sequence
10
MDPTCSSECI
20
YNLIPSDLKE
30
PPQPPRYISI
40
FKATVKDDMQ
50
KAKTAMKTMG
60
PAKVEVPSPK
70
DFLKKHSKEK
80
TLPPKKNFDR
90
NVPKKPAVPL
100
KTDHPVMGIQ
110
SGKNFINTNA
120
ADIIMGVAKK
130
PKPIYVDKRT
140
GDKHDLEPSG
150
LVPKYINKKD
160
YGVTPEYICK
170
RNEEIKKAQE
180
DYDRYIQENL
190
KKAAMKRLSD
200
EEREAVLQGL
210
KKNWEEVHKE
220
FQSLSVFIDS
230
IPKKIRKQRL
240
EEEMKQLEHD
250
IGIIEKHKII
YIANNA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0097728 | 9+0 motile cilium |
| Cellular Component | GO:0097729 | 9+2 motile cilium |
| Cellular Component | GO:0001669 | acrosomal vesicle |
| Cellular Component | GO:0160112 | axonemal B tubule inner sheath |
| Cellular Component | GO:0005879 | axonemal microtubule |
| Cellular Component | GO:0036126 | sperm flagellum |
| Cellular Component | GO:0097225 | sperm midpiece |
| Cellular Component | GO:0097228 | sperm principal piece |
| Molecular Function | GO:0005516 | calmodulin binding |
| Molecular Function | GO:0017124 | SH3 domain binding |
| Biological Process | GO:0061966 | establishment of left/right asymmetry |
| Biological Process | GO:0030317 | flagellated sperm motility |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.
[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.