Overview
| Uniprot ID | Q8TC36 |
|---|
| Protein Name | SUN domain-containing protein 5 |
|---|
| Gene Name | SUN5 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 95 |
LFNTCRCKLLCQKLM |
Function
Required for male fertility (PubMed:38870534). Plays an essential role in maintenance of sperm head-to-tail attachment during late stages of spermiogenesis, via promoting secure attachment of the nuclear envelop to the flagellum coupling apparatus (Probable) (PubMed:38870534). Component of the LMNB1/SUN5/SEPT12 bridge that connects the sperm proximal centriole to the implantation fossa, the bridge functions to prevent detachment of the proximal centriole from the posterior nucleus during spermiogenesis (PubMed:38870534). Required for localization of SEPT12 at the implantation fossa of sperm cells during spermiogenesis (By similarity)
Protein Sequence
10
MPRSSRSPGD
20
PGALLEDVAH
30
NPRPRRIAQR
40
GRNTSRMAED
50
TSPNMNDNIL
60
LPVRNNDQAL
70
GLTQCMLGCV
80
SWFTCFACSL
90
RTQAQQVLFN
100
TCRCKLLCQK
110
LMEKTGILLL
120
CAFGFWMFSI
130
HLPSKMKVWQ
140
DDSINGPLQS
150
LRLYQEKVRH
160
HSGEIQDLRG
170
SMNQLIAKLQ
180
EMEAMSDEQK
190
MAQKIMKMIH
200
GDYIEKPDFA
210
LKSIGASIDF
220
EHTSVTYNHE
230
KAHSYWNWIQ
240
LWNYAQPPDV
250
ILEPNVTPGN
260
CWAFEGDRGQ
270
VTIQLAQKVY
280
LSNLTLQHIP
290
KTISLSGSLD
300
TAPKDFVIYG
310
MEGSPKEEVF
320
LGAFQFQPEN
330
IIQMFPLQNQ
340
PARAFSAVKV
350
KISSNWGNPG
360
FTCLYRVRVH
370
GSVAPPREQP
HQNPYPKRD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005794 |
Golgi apparatus |
| Cellular Component |
GO:0034993 |
meiotic nuclear membrane microtubule tethering complex |
| Cellular Component |
GO:0005635 |
nuclear envelope |
| Cellular Component |
GO:0005637 |
nuclear inner membrane |
| Cellular Component |
GO:0120212 |
sperm head-tail coupling apparatus |
| Molecular Function |
GO:0043495 |
protein-membrane adaptor activity |
| Biological Process |
GO:0007286 |
spermatid development |
| Biological Process |
GO:0007283 |
spermatogenesis |
Reference
[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.