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Overview

Uniprot ID	Q8TCF1
Protein Name	AN1-type zinc finger protein 1
Gene Name	ZFAND1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
113	PRMAATQKLVKDIID
116	AATQKLVKDIIDSKT
122	VKDIIDSKTGETASK
135	SKRWKGAKNSETAAK

Function

Plays a role in the regulation of cytoplasmic stress granules (SGs) turnover. SGs are dynamic and transient cytoplasmic ribonucleoprotein assemblies important for cellular protein homeostasis when protein production is suspended after acute exogenous stress (PubMed:29804830). Associates with SGs and is involved in the efficient and specific arsenite-induced clearance process of SGs through the recruitment of the ubiquitin-selective ATPase VCP and the 26S proteasome (PubMed:29804830). This process requires both complexes for efficient degradation of damaged ubiquitinated SG proteins during recovery from arsenite stress, and hence avoiding aberrant cytoplasmic SGs degradation via autophagy (PubMed:29804830)

Protein Sequence

10 MAELDIGQHC 20 QVEHCRQRDF 30 LPFVCDDCSG 40 IFCLEHRSRE 50 SHGCPEVTVI 60 NERLKTDQHT 70 SYPCSFKDCA 80 ERELVAVICP 90 YCEKNFCLRH 100 RHQSDHECEK 110 LEIPKPRMAA 120 TQKLVKDIID 130 SKTGETASKR 140 WKGAKNSETA 150 AKVALMKLKM 160 HADGDKSLPQ 170 TERIYFQVFL 180 PKGSKEKSKP 190 MFFCHRWSIG 200 KAIDFAASLA 210 RLKNDNNKFT 220 AKKLRLCHIT 230 SGEALPLDHT 240 LETWIAKEDC 250 PLYNGGNIIL 260 EYLNDEEQFC KNVESYLE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0010494	cytoplasmic stress granule
Molecular Function	GO:0070628	proteasome binding
Molecular Function	GO:0008270	zinc ion binding
Biological Process	GO:1903843	cellular response to arsenite ion
Biological Process	GO:0090316	positive regulation of intracellular protein transport
Biological Process	GO:0035617	stress granule disassembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.