Search Results
Overview
| Uniprot ID | Q8TD22 |
|---|---|
| Protein Name | Sideroflexin-5 |
| Gene Name | SFXN5 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 190 | VLVQKANKFTPATRL |
Function
Mitochondrial amino-acid transporter (By similarity). Transports citrate (By similarity). Does not act as a serine transporter: not able to mediate transport of serine into mitochondria (By similarity) (PubMed:30442778). In brown adipose tissue, plays a role in the regulation of UCP1-dependent thermogenesis probably by supporting mitochondrial glycerol-3-phosphate utilization (By similarity)
Protein Sequence
10
MADTATTASA
20
AAASAASASS
30
DAPPFQLGKP
40
RFQQTSFYGR
50
FRHFLDIIDP
60
RTLFVTERRL
70
REAVQLLEDY
80
KHGTLRPGVT
90
NEQLWSAQKI
100
KQAILHPDTN
110
EKIFMPFRMS
120
GYIPFGTPIV
130
VGLLLPNQTL
140
ASTVFWQWLN
150
QSHNACVNYA
160
NRNATKPSPA
170
SKFIQGYLGA
180
VISAVSIAVG
190
LNVLVQKANK
200
FTPATRLLIQ
210
RFVPFPAVAS
220
ANICNVVLMR
230
YGELEEGIDV
240
LDSDGNLVGS
250
SKIAARHALL
260
ETALTRVVLP
270
MPILVLPPIV
280
MSMLEKTALL
290
QARPRLLLPV
300
QSLVCLAAFG
310
LALPLAISLF
320
PQMSEIETSQ
330
LEPEIAQATS
340
SRTVVYNKGL
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0015137 | citrate transmembrane transporter activity |
| Molecular Function | GO:0015075 | monoatomic ion transmembrane transporter activity |
| Biological Process | GO:0006865 | amino acid transport |
| Biological Process | GO:0015746 | citrate transport |
| Biological Process | GO:1990542 | mitochondrial transmembrane transport |
| Biological Process | GO:0120162 | positive regulation of cold-induced thermogenesis |
Reference
[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.