Search Results

Overview

Uniprot IDQ8TD57
Protein NameDynein axonemal heavy chain 3
Gene NameDNAH3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1721 GGKTSAYKVLAAALG
2875 EFQPAVIKNVSSACE

Function

Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity). Essential for the assembly and structural organization of the sperm flagellum's axoneme, including its inner dynein arms and accessory components, which are critical for maintaining flagellar integrity and motility (PubMed:39503742, PubMed:38312775)

Protein Sequence

10 MGATGRLELT 20 LAAPPHPGPA 30 FQRSKARETQ 40 GEEEGSEMQI 50 AKSDSIHHMS 60 HSQGQPELPP 70 LPASANEEPS 80 GLYQTVMSHS 90 FYPPLMQRTS 100 WTLAAPFKEQ 110 HHHRGPSDSI 120 ANNYSLMAQD 130 LKLKDLLKVY 140 QPATISVPRD 150 RTGQGLPSSG 160 NRSSSEPMRK 170 KTKFSSRNKE 180 DSTRIKLAFK 190 TSIFSPMKKE 200 VKTSLTFPGS 210 RPMSPEQQLD 220 VMLQQEMEME 230 SKEKKPSESD 240 LERYYYYLTN 250 GIRKDMIAPE 260 EGEVMVRISK 270 LISNTLLTSP 280 FLEPLMVVLV 290 QEKENDYYCS 300 LMKSIVDYIL 310 MDPMERKRLF 320 IESIPRLFPQ 330 RVIRAPVPWH 340 SVYRSAKKWN 350 EEHLHTVNPM 360 MLRLKELWFA 370 EFRDLRFVRT 380 AEILAGKLPL 390 QPQEFWDVIQ 400 KHCLEAHQTL 410 LNKWIPTCAQ 420 LFTSRKEHWI 430 HFAPKSNYDS 440 SRNIEEYFAS 450 VASFMSLQLR 460 ELVIKSLEDL 470 VSLFMIHKDG 480 NDFKEPYQEM 490 KFFIPQLIMI 500 KLEVSEPIIV 510 FNPSFDGCWE 520 LIRDSFLEII 530 KNSNGIPKLK 540 YIPLKFSFTA 550 AAADRQCVKA 560 AEPGEPSMHA 570 AATAMAELKG 580 YNLLLGTVNA 590 EEKLVSDFLI 600 QTFKVFQKNQ 610 VGPCKYLNVY 620 KKYVDLLDNT 630 AEQNIAAFLK 640 ENHDIDDFVT 650 KINAIKKRRN 660 EIASMNITVP 670 LAMFCLDATA 680 LNHDLCERAQ 690 NLKDHLIQFQ 700 VDVNRDTNTS 710 ICNQYSHIAD 720 KVSEVPANTK 730 ELVSLIEFLK 740 KSSAVTVFKL 750 RRQLRDASER 760 LEFLMDYADL 770 PYQIEDIFDN 780 SRNLLLHKRD 790 QAEMDLIKRC 800 SEFELRLEGY 810 HRELESFRKR 820 EVMTTEEMKH 830 NVEKLNELSK 840 NLNRAFAEFE 850 LINKEEELLE 860 KEKSTYPLLQ 870 AMLKNKVPYE 880 QLWSTAYEFS 890 IKSEEWMNGP 900 LFLLNAEQIA 910 EEIGNMWRTT 920 YKLIKTLSDV 930 PAPRRLAENV 940 KIKIDKFKQY 950 IPILSISCNP 960 GMKDRHWQQI 970 SEIVGYEIKP 980 TETTCLSNML 990 EFGFGKFVEK 1000 LEPIGAAASK 1010 EYSLEKNLDR 1020 MKLDWVNVTF 1030 SFVKYRDTDT 1040 NILCAIDDIQ 1050 MLLDDHVIKT 1060 QTMCGSPFIK 1070 PIEAECRKWE 1080 EKLIRIQDNL 1090 DAWLKCQATW 1100 LYLEPIFSSE 1110 DIIAQMPEEG 1120 RKFGIVDSYW 1130 KSLMSQAVKD 1140 NRILVAADQP 1150 RMAEKLQEAN 1160 FLLEDIQKGL 1170 NDYLEKKRLF 1180 FPRFFFLSND 1190 ELLEILSETK 1200 DPLRVQPHLK 1210 KCFEGIAKLE 1220 FTDNLEIVGM 1230 ISSEKETVPF 1240 IQKIYPANAK 1250 GMVEKWLQQV 1260 EQMMLASMRE 1270 VIGLGIEAYV 1280 KVPRNHWVLQ 1290 WPGQVVICVS 1300 SIFWTQEVSQ 1310 ALAENTLLDF 1320 LKKSNDQIAQ 1330 IVQLVRGKLS 1340 SGARLTLGAL 1350 TVIDVHARDV 1360 VAKLSEDRVS 1370 DLNDFQWISQ 1380 LRYYWVAKDV 1390 QVQIITTEAL 1400 YGYEYLGNSP 1410 RLVITPLTDR 1420 CYRTLMGALK 1430 LNLGGAPEGP 1440 AGTGKTETTK 1450 DLAKALAKQC 1460 VVFNCSDGLD 1470 YKAMGKFFKG 1480 LAQAGAWACF 1490 DEFNRIEVEV 1500 LSVVAQQILS 1510 IQQAIIRKLK 1520 TFIFEGTELS 1530 LNPTCAVFIT 1540 MNPGYAGRAE 1550 LPDNLKALFR 1560 TVAMMVPDYA 1570 LIGEISLYSM 1580 GFLDSRSLAQ 1590 KIVATYRLCS 1600 EQLSSQHHYD 1610 YGMRAVKSVL 1620 TAAGNLKLKY 1630 PEENESVLLL 1640 RALLDVNLAK 1650 FLAQDVPLFQ 1660 GIISDLFPGV 1670 VLPKPDYEVF 1680 LKVLNDNIKK 1690 MKLQPVPWFI 1700 GKIIQIYEMM 1710 LVRHGYMIVG 1720 DPMGGKTSAY 1730 KVLAAALGDL 1740 HAANQMEEFA 1750 VEYKIINPKA 1760 ITMGQLYGCF 1770 DQVSHEWMDG 1780 VLANAFREQA 1790 SSLSDDRKWI 1800 IFDGPVDAIW 1810 IENMNTVLDD 1820 NKKLCLMSGE 1830 IIQMNSKMSL 1840 IFEPADLEQA 1850 SPATVSRCGM 1860 IYMEPHQLGW 1870 KPLKDSYMDT 1880 LPSSLTKEHK 1890 ELVNDMFMWL 1900 VQPCLEFGRL 1910 HCKFVVQTSP 1920 IHLAFSMMRL 1930 YSSLLDEIRA 1940 VEEEEMELGE 1950 GLSSQQIFLW 1960 LQGLFLFSLV 1970 WTVAGTINAD 1980 SRKKFDVFFR 1990 NLIMGMDDNH 2000 PRPKSVKLTK 2010 NNIFPERGSI 2020 YDFYFIKQAS 2030 GHWETWTQYI 2040 TKEEEKVPAG 2050 AKVSELIIPT 2060 METARQSFFL 2070 KTYLDHEIPM 2080 LFVGPTGTGK 2090 SAITNNFLLH 2100 LPKNTYLPNC 2110 INFSARTSAN 2120 QTQDIIMSKL 2130 DRRRKGLFGP 2140 PIGKKAVVFV 2150 DDLNMPAKEV 2160 YGAQPPIELL 2170 RQWIDHGYWF 2180 DKKDTTRLDI 2190 VDMLLVTAMG 2200 PPGGGRNDIT 2210 GRFTRHLNII 2220 SINAFEDDIL 2230 TKIFSSIVDW 2240 HFGKGFDVMF 2250 LRYGKMLVQA 2260 TKTIYRDAVE 2270 NFLPTPSKSH 2280 YVFNLRDFSR 2290 VIQGVLLCPH 2300 THLQDVEKCI 2310 RLWIHEVYRV 2320 FYDRLIDKED 2330 RQVFFNMVKE 2340 TTSNCFKQTI 2350 EKVLIHLSPT 2360 GKIVDDNIRS 2370 LFFGDYFKPE 2380 SDQKIYDEIT 2390 DLKQLTVVME 2400 HYLEEFNNIS 2410 KAPMSLVMFR 2420 FAIEHISRIC 2430 RVLKQDKGHL 2440 LLVGIGGSGR 2450 QSAAKLSTFM 2460 NAYELYQIEI 2470 TKNYAGNDWR 2480 EDLKKIILQV 2490 GVATKSTVFL 2500 FADNQIKDES 2510 FVEDINMLLN 2520 TGDVPNIFPA 2530 DEKADIVEKM 2540 QTAARTQGEK 2550 VEVTPLSMYN 2560 FFIERVINKI 2570 SFSLAMSPIG 2580 DAFRNRLRMF 2590 PSLINCCTID 2600 WFQSWPTDAL 2610 ELVANKFLED 2620 VELDDNIRVE 2630 VVSMCKYFQE 2640 SVKKLSLDYY 2650 NKLRRHNYVT 2660 PTSYLELILT 2670 FKTLLNSKRQ 2680 EVAMMRNRYL 2690 TGLQKLDFAA 2700 SQVAVMQREL 2710 TALQPQLILT 2720 SEETAKMMVK 2730 IEAETREADG 2740 KKLLVQADEK 2750 EANVAAAIAQ 2760 GIKNECEGDL 2770 AEAMPALEAA 2780 LAALDTLNPA 2790 DISLVKSMQN 2800 PPGPVKLVME 2810 SICIMKGMKP 2820 ERKPDPSGSG 2830 KMIEDYWGVS 2840 KKILGDLKFL 2850 ESLKTYDKDN 2860 IPPLTMKRIR 2870 ERFINHPEFQ 2880 PAVIKNVSSA 2890 CEGLCKWVRA 2900 MEVYDRVAKV 2910 VAPKRERLRE 2920 AEGKLAAQMQ 2930 KLNQKRAELK 2940 LVVDRLQALN 2950 DDFEEMNTKK 2960 KDLEENIEIC 2970 SQKLVRAEKL 2980 ISGLGGEKDR 2990 WTEAARQLGI 3000 RYTNLTGDVL 3010 LSSGTVAYLG 3020 AFTVDYRVQC 3030 QNQWLAECKD 3040 KVIPGFSDFS 3050 LSHTLGDPIK 3060 IRAWQIAGLP 3070 VDSFSIDNGI 3080 IVSNSRRWAL 3090 MIDPHGQANK 3100 WIKNMEKANK 3110 LAVIKFSDSN 3120 YMRMLENALQ 3130 LGTPVLIENI 3140 GEELDASIEP 3150 ILLKATFKQQ 3160 GVEYMRLGEN 3170 IIEYSRDFKL 3180 YITTRLRNPH 3190 YLPEVAVKVC 3200 LLNFMITPLG 3210 LQDQLLGIVA 3220 AKEKPELEEK 3230 KNQLIVESAK 3240 NKKHLKEIED 3250 KILEVLSMSK 3260 GNILEDETAI 3270 KVLSSSKVLS 3280 EEISEKQKVA 3290 SMTETQIDET 3300 RMGYKPVAVH 3310 SATIFFCISD 3320 LANIEPMYQY 3330 SLTWFINLYM 3340 HSLTHSTKSE 3350 ELNLRIKYII 3360 DHFTLSIYNN 3370 VCRSLFEKDK 3380 LLFSLLLTIG 3390 IMKQKKEITE 3400 EVWYFLLTGG 3410 IALDNPYPNP 3420 APQWLSEKAW 3430 AEIVRASALP 3440 KLHGLMEHLE 3450 QNLGEWKLIY 3460 DSAWPHEEQL 3470 PGSWKFSQGL 3480 EKMVILRCLR 3490 PDKMVPAVRE 3500 FIAEHMGKLY 3510 IEAPTFDLQG 3520 SYNDSSCCAP 3530 LIFVLSPSAD 3540 PMAGLLKFAD 3550 DLGMGGTRTQ 3560 TISLGQGQGP 3570 IAAKMINNAI 3580 KDGTWVVLQN 3590 CHLAASWMPT 3600 LEKICEEVIV 3610 PESTNARFRL 3620 WLTSYPSEKF 3630 PVSILQNGIK 3640 MTNEPPKGLR 3650 ANLLRSYLND 3660 PISDPVFFQS 3670 CAKAVMWQKM 3680 LFGLCFFHAV 3690 VQERRNFGPL 3700 GWNIPYEFNE 3710 SDLRISMWQI 3720 QMFLNDYKEV 3730 PFDALTYLTG 3740 ECNYGGRVTD 3750 DKDRRLLLSL 3760 LSMFYCKEIE 3770 EDYYSLAPGD 3780 TYYIPPHGSY 3790 QSYIDYLRNL 3800 PITAHPEVFG 3810 LHENADITKD 3820 NQETNQLFEG 3830 VLLTLPRQSG 3840 GSGKSPQEVV 3850 EELAQDILSK 3860 LPRDFDLEEV 3870 MKLYPVVYEE 3880 SMNTVLRQEL 3890 IRFNRLTKVV 3900 RRSLINLGRA 3910 IKGQVLMSSE 3920 LEEVFNSMLV 3930 GKVPAMWAAK 3940 SYPSLKPLGG 3950 YVADLLARLT 3960 FFQEWIDKGP 3970 PVVFWISGFY 3980 FTQSFLTGVS 3990 QNYARKYTIP 4000 IDHIGFEFEV 4010 TPQETVMENN 4020 PEDGAYIKGL 4030 FLEGARWDRK 4040 TMQIGESLPK 4050 ILYDPLPIIW 4060 LKPGESAMFL 4070 HQDIYVCPVY 4080 KTSARRGTLS 4090 TTGHSTNYVL 4100 SIELPTDMPQ 4110 KHWINRGVAS LCQLDN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097729 9+2 motile cilium
Cellular Component GO:0005858 axonemal dynein complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0036156 inner dynein arm
Cellular Component GO:0005874 microtubule
Cellular Component GO:0036126 sperm flagellum
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0060294 cilium movement involved in cell motility
Biological Process GO:0060285 cilium-dependent cell motility
Biological Process GO:0036159 inner dynein arm assembly
Biological Process GO:0007288 sperm axoneme assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.