Search Results
Overview
| Uniprot ID | Q8TDD2 |
|---|---|
| Protein Name | Transcription factor Sp7 |
| Gene Name | SP7 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 247 | LEGSGGAKPPRGAST |
Function
Transcriptional activator essential for osteoblast differentiation (PubMed:23457570). Binds to SP1 and EKLF consensus sequences and to other G/C-rich sequences (By similarity)
Protein Sequence
10
MASSLLEEEV
20
HYGSSPLAML
30
TAACSKFGGS
40
SPLRDSTTLG
50
KAGTKKPYSV
60
GSDLSASKTM
70
GDAYPAPFTS
80
TNGLLSPAGS
90
PPAPTSGYAN
100
DYPPFSHSFP
110
GPTGTQDPGL
120
LVPKGHSSSD
130
CLPSVYTSLD
140
MTHPYGSWYK
150
AGIHAGISPG
160
PGNTPTPWWD
170
MHPGGNWLGG
180
GQGQGDGLQG
190
TLPTGPAQPP
200
LNPQLPTYPS
210
DFAPLNPAPY
220
PAPHLLQPGP
230
QHVLPQDVYK
240
PKAVGNSGQL
250
EGSGGAKPPR
260
GASTGGSGGY
270
GGSGAGRSSC
280
DCPNCQELER
290
LGAAAAGLRK
300
KPIHSCHIPG
310
CGKVYGKASH
320
LKAHLRWHTG
330
ERPFVCNWLF
340
CGKRFTRSDE
350
LERHVRTHTR
360
EKKFTCLLCS
370
KRFTRSDHLS
380
KHQRTHGEPG
390
PGPPPSGPKE
400
LGEGRSTGEE
410
EASQTPRPSA
420
SPATPEKAPG
430
GSPEQSNLLE
I
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0017151 | DEAD/H-box RNA helicase binding |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific |
| Molecular Function | GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific |
| Molecular Function | GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071529 | cementum mineralization |
| Biological Process | GO:0071344 | diphosphate metabolic process |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0060218 | hematopoietic stem cell differentiation |
| Biological Process | GO:0001649 | osteoblast differentiation |
| Biological Process | GO:2000738 | positive regulation of stem cell differentiation |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
Reference
PMID: N/A