Search Results

Overview

Uniprot ID	Q8TDN6
Protein Name	Ribosome biogenesis protein BRX1 homolog
Gene Name	BRIX1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
17	GGFAVQAKKPKRNEI
18	GFAVQAKKPKRNEID
276	IRSITAAKYREKQQV
284	YREKQQVKDVQKLRK
31	IDAEPPAKRHATAEE
53	RIPGPVCKGKWKNKE

Function

Required for biogenesis of the 60S ribosomal subunit

Protein Sequence

10 MAATKRKRRG 20 GFAVQAKKPK 30 RNEIDAEPPA 40 KRHATAEEVE 50 EEERDRIPGP 60 VCKGKWKNKE 70 RILIFSSRGI 80 NFRTRHLMQD 90 LRMLMPHSKA 100 DTKMDRKDKL 110 FVINEVCEMK 120 NCNKCIYFEA 130 KKKQDLYMWL 140 SNSPHGPSAK 150 FLVQNIHTLA 160 ELKMTGNCLK 170 GSRPLLSFDP 180 AFDELPHYAL 190 LKELLIQIFS 200 TPRYHPKSQP 210 FVDHVFTFTI 220 LDNRIWFRNF 230 QIIEEDAALV 240 EIGPRFVLNL 250 IKIFQGSFGG 260 PTLYENPHYQ 270 SPNMHRRVIR 280 SITAAKYREK 290 QQVKDVQKLR 300 KKEPKTLLPH 310 DPTADVFVTP 320 AEEKPIEIQW 330 VKPEPKVDLK 340 ARKKRIYKRQ 350 RKMKQRMDSG KTK

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005694	chromosome
Cellular Component	GO:0005730	nucleolus
Molecular Function	GO:0003723	RNA binding
Molecular Function	GO:0019843	rRNA binding
Biological Process	GO:0000027	ribosomal large subunit assembly
Biological Process	GO:0006364	rRNA processing

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.