Search Results

Overview

Uniprot IDQ8TE73
Protein NameDynein axonemal heavy chain 5
Gene NameDNAH5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
2020 RGLGRIFKGLAQSGS

Function

Force generating protein of respiratory cilia (By similarity). Produces force towards the minus ends of microtubules (By similarity). Key component of dynein, a family of motor proteins essential for movement along microtubules (By similarity). Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity). Required for structural and functional integrity of the cilia of ependymal cells lining the brain ventricles (By similarity)

Protein Sequence

10 MFRIGRRQLW 20 KHSVTRVLTQ 30 RLKGEKEAKR 40 ALLDARHNYL 50 FAIVASCLDL 60 NKTEVEDAIL 70 EGNQIERIDQ 80 LFAVGGLRHL 90 MFYYQDVEEA 100 ETGQLGSLGG 110 VNLVSGKIKK 120 PKVFVTEGND 130 VALTGVCVFF 140 IRTDPSKAIT 150 PDNIHQEVSF 160 NMLDAADGGL 170 LNSVRRLLSD 180 IFIPALRATS 190 HGWGELEGLQ 200 DAANIRQEFL 210 SSLEGFVNVL 220 SGAQESLKEK 230 VNLRKCDILE 240 LKTLKEPTDY 250 LTLANNPETL 260 GKIEDCMKVW 270 IKQTEQVLAE 280 NNQLLKEADD 290 VGPRAELEHW 300 KKRLSKFNYL 310 LEQLKSPDVK 320 AVLAVLAAAK 330 SKLLKTWREM 340 DIRITDATNE 350 AKDNVKYLYT 360 LEKCCDPLYS 370 SDPLSMMDAI 380 PTLINAIKMI 390 YSISHYYNTS 400 EKITSLFVKV 410 TNQIISACKA 420 YITNNGTASI 430 WNQPQDVVEE 440 KILSAIKLKQ 450 EYQLCFHKTK 460 QKLKQNPNAK 470 QFDFSEMYIF 480 GKFETFHRRL 490 AKIIDIFTTL 500 KTYSVLQDST 510 IEGLEDMATK 520 YQGIVATIKK 530 KEYNFLDQRK 540 MDFDQDYEEF 550 CKQTNDLHNE 560 LRKFMDVTFA 570 KIQNTNQALR 580 MLKKFERLNI 590 PNLGIDDKYQ 600 LILENYGADI 610 DMISKLYTKQ 620 KYDPPLARNQ 630 PPIAGKILWA 640 RQLFHRIQQP 650 MQLFQQHPAV 660 LSTAEAKPII 670 RSYNRMAKVL 680 LEFEVLFHRA 690 WLRQIEEIHV 700 GLEASLLVKA 710 PGTGELFVNF 720 DPQILILFRE 730 TECMAQMGLE 740 VSPLATSLFQ 750 KRDRYKRNFS 760 NMKMMLAEYQ 770 RVKSKIPAAI 780 EQLIVPHLAK 790 VDEALQPGLA 800 ALTWTSLNIE 810 AYLENTFAKI 820 KDLELLLDRV 830 NDLIEFRIDA 840 ILEEMSSTPL 850 CQLPQEEPLT 860 CEEFLQMTKD 870 LCVNGAQILH 880 FKSSLVEEAV 890 NELVNMLLDV 900 EVLSEEESEK 910 ISNENSVNYK 920 NESSAKREEG 930 NFDTLTSSIN 940 ARANALLLTT 950 VTRKKKETEM 960 LGEEARELLS 970 HFNHQNMDAL 980 LKVTRNTLEA 990 IRKRIHSSHT 1000 INFRDSNSAS 1010 NMKQNSLPIF 1020 RASVTLAIPN 1030 IVMAPALEDV 1040 QQTLNKAVEC 1050 IISVPKGVRQ 1060 WSSELLSKKK 1070 IQERKMAALQ 1080 SNEDSDSDVE 1090 MGENELQDTL 1100 EIASVNLPIP 1110 VQTKNYYKNV 1120 SENKEIVKLV 1130 SVLSTIINST 1140 KKEVITSMDC 1150 FKRYNHIWQK 1160 GKEEAIKTFI 1170 TQSPLLSEFE 1180 SQILYFQNLE 1190 QEINAEPEYV 1200 CVGSIALYTA 1210 DLKFALTAET 1220 KAWMVVIGRH 1230 CNKKYRSEME 1240 NIFMLIEEFN 1250 KKLNRPIKDL 1260 DDIRIAMAAL 1270 KEIREEQISI 1280 DFQVGPIEES 1290 YALLNRYGLL 1300 IAREEIDKVD 1310 TLHYAWEKLL 1320 ARAGEVQNKL 1330 VSLQPSFKKE 1340 LISAVEVFLQ 1350 DCHQFYLDYD 1360 LNGPMASGLK 1370 PQEASDRLIM 1380 FQNQFDNIYR 1390 KYITYTGGEE 1400 LFGLPATQYP 1410 QLLEIKKQLN 1420 LLQKIYTLYN 1430 SVIETVNSYY 1440 DILWSEVNIE 1450 KINNELLEFQ 1460 NRCRKLPRAL 1470 KDWQAFLDLK 1480 KIIDDFSECC 1490 PLLEYMASKA 1500 MMERHWERIT 1510 TLTGHSLDVG 1520 NESFKLRNIM 1530 EAPLLKYKEE 1540 IEDICISAVK 1550 ERDIEQKLKQ 1560 VINEWDNKTF 1570 TFGSFKTRGE 1580 LLLRGDSTSE 1590 IIANMEDSLM 1600 LLGSLLSNRY 1610 NMPFKAQIQK 1620 WVQYLSNSTD 1630 IIESWMTVQN 1640 LWIYLEAVFV 1650 GGDIAKQLPK 1660 EAKRFSNIDK 1670 SWVKIMTRAH 1680 EVPSVVQCCV 1690 GDETLGQLLP 1700 HLLDQLEICQ 1710 KSLTGYLEKK 1720 RLCFPRFFFV 1730 SDPALLEILG 1740 QASDSHTIQA 1750 HLLNVFDNIK 1760 SVKFHEKIYD 1770 RILSISSQEG 1780 ETIELDKPVM 1790 AEGNVEVWLN 1800 SLLEESQSSL 1810 HLVIRQAAAN 1820 IQETGFQLTE 1830 FLSSFPAQVG 1840 LLGIQMIWTR 1850 DSEEALRNAK 1860 FDKKIMQKTN 1870 QAFLELLNTL 1880 IDVTTRDLSS 1890 TERVKYETLI 1900 TIHVHQRDIF 1910 DDLCHMHIKS 1920 PMDFEWLKQC 1930 RFYFNEDSDK 1940 MMIHITDVAF 1950 IYQNEFLGCT 1960 DRLVITPLTD 1970 RCYITLAQAL 1980 GMSMGGAPAG 1990 PAGTGKTETT 2000 KDMGRCLGKY 2010 VVVFNCSDQM 2020 DFRGLGRIFK 2030 GLAQSGSWGC 2040 FDEFNRIDLP 2050 VLSVAAQQIS 2060 IILTCKKEHK 2070 KSFIFTDGDN 2080 VTMNPEFGLF 2090 LTMNPGYAGR 2100 QELPENLKIN 2110 FRSVAMMVPD 2120 RQIIIRVKLA 2130 SCGFIDNVVL 2140 ARKFFTLYKL 2150 CEEQLSKQVH 2160 YDFGLRNILS 2170 VLRTLGAAKR 2180 ANPMDTESTI 2190 VMRVLRDMNL 2200 SKLIDEDEPL 2210 FLSLIEDLFP 2220 NILLDKAGYP 2230 ELEAAISRQV 2240 EEAGLINHPP 2250 WKLKVIQLFE 2260 TQRVRHGMMT 2270 LGPSGAGKTT 2280 CIHTLMRAMT 2290 DCGKPHREMR 2300 MNPKAITAPQ 2310 MFGRLDVATN 2320 DWTDGIFSTL 2330 WRKTLRAKKG 2340 EHIWIILDGP 2350 VDAIWIENLN 2360 SVLDDNKTLT 2370 LANGDRIPMA 2380 PNCKIIFEPH 2390 NIDNASPATV 2400 SRNGMVFMSS 2410 SILDWSPILE 2420 GFLKKRSPQE 2430 AEILRQLYTE 2440 SFPDLYRFCI 2450 QNLEYKMEVL 2460 EAFVITQSIN 2470 MLQGLIPLKE 2480 QGGEVSQAHL 2490 GRLFVFALLW 2500 SAGAALELDG 2510 RRRLELWLRS 2520 RPTGTLELPP 2530 PAGPGDTAFD 2540 YYVAPDGTWT 2550 HWNTRTQEYL 2560 YPSDTTPEYG 2570 SILVPNVDNV 2580 RTDFLIQTIA 2590 KQGKAVLLIG 2600 EQGTAKTVII 2610 KGFMSKYDPE 2620 CHMIKSLNFS 2630 SATTPLMFQR 2640 TIESYVDKRM 2650 GTTYGPPAGK 2660 KMTVFIDDVN 2670 MPIINEWGDQ 2680 VTNEIVRQLM 2690 EQNGFYNLEK 2700 PGEFTSIVDI 2710 QFLAAMIHPG 2720 GGRNDIPQRL 2730 KRQFSIFNCT 2740 LPSEASVDKI 2750 FGVIGVGHYC 2760 TQRGFSEEVR 2770 DSVTKLVPLT 2780 RRLWQMTKIK 2790 MLPTPAKFHY 2800 VFNLRDLSRV 2810 WQGMLNTTSE 2820 VIKEPNDLLK 2830 LWKHECKRVI 2840 ADRFTVSSDV 2850 TWFDKALVSL 2860 VEEEFGEEKK 2870 LLVDCGIDTY 2880 FVDFLRDAPE 2890 AAGETSEEAD 2900 AETPKIYEPI 2910 ESFSHLKERL 2920 NMFLQLYNES 2930 IRGAGMDMVF 2940 FADAMVHLVK 2950 ISRVIRTPQG 2960 NALLVGVGGS 2970 GKQSLTRLAS 2980 FIAGYVSFQI 2990 TLTRSYNTSN 3000 LMEDLKVLYR 3010 TAGQQGKGIT 3020 FIFTDNEIKD 3030 ESFLEYMNNV 3040 LSSGEVSNLF 3050 ARDEIDEINS 3060 DLASVMKKEF 3070 PRCLPTNENL 3080 HDYFMSRVRQ 3090 NLHIVLCFSP 3100 VGEKFRNRAL 3110 KFPALISGCT 3120 IDWFSRWPKD 3130 ALVAVSEHFL 3140 TSYDIDCSLE 3150 IKKEVVQCMG 3160 SFQDGVAEKC 3170 VDYFQRFRRS 3180 THVTPKSYLS 3190 FIQGYKFIYG 3200 EKHVEVRTLA 3210 NRMNTGLEKL 3220 KEASESVAAL 3230 SKELEAKEKE 3240 LQVANDKADM 3250 VLKEVTMKAQ 3260 AAEKVKAEVQ 3270 KVKDRAQAIV 3280 DSISKDKAIA 3290 EEKLEAAKPA 3300 LEEAEAALQT 3310 IRPSDIATVR 3320 TLGRPPHLIM 3330 RIMDCVLLLF 3340 QRKVSAVKID 3350 LEKSCTMPSW 3360 QESLKLMTAG 3370 NFLQNLQQFP 3380 KDTINEEVIE 3390 FLSPYFEMPD 3400 YNIETAKRVC 3410 GNVAGLCSWT 3420 KAMASFFSIN 3430 KEVLPLKANL 3440 VVQENRHLLA 3450 MQDLQKAQAE 3460 LDDKQAELDV 3470 VQAEYEQAMT 3480 EKQTLLEDAE 3490 RCRHKMQTAS 3500 TLISGLAGEK 3510 ERWTEQSQEF 3520 AAQTKRLVGD 3530 VLLATAFLSY 3540 SGPFNQEFRD 3550 LLLNDWRKEM 3560 KARKIPFGKN 3570 LNLSEMLIDA 3580 PTISEWNLQG 3590 LPNDDLSIQN 3600 GIIVTKASRY 3610 PLLIDPQTQG 3620 KIWIKNKESR 3630 NELQITSLNH 3640 KYFRNHLEDS 3650 LSLGRPLLIE 3660 DVGEELDPAL 3670 DNVLERNFIK 3680 TGSTFKVKVG 3690 DKEVDVLDGF 3700 RLYITTKLPN 3710 PAYTPEISAR 3720 TSIIDFTVTM 3730 KGLEDQLLGR 3740 VILTEKQELE 3750 KERTHLMEDV 3760 TANKRRMKEL 3770 EDNLLYRLTS 3780 TQGSLVEDES 3790 LIVVLSNTKR 3800 TAEEVTQKLE 3810 ISAETEVQIN 3820 SAREEYRPVA 3830 TRGSILYFLI 3840 TEMRLVNEMY 3850 QTSLRQFLGL 3860 FDLSLARSVK 3870 SPITSKRIAN 3880 IIEHMTYEVY 3890 KYAARGLYEE 3900 HKFLFTLLLT 3910 LKIDIQRNRV 3920 KHEEFLTLIK 3930 GGASLDLKAC 3940 PPKPSKWILD 3950 ITWLNLVELS 3960 KLRQFSDVLD 3970 QISRNEKMWK 3980 IWFDKENPEE 3990 EPLPNAYDKS 4000 LDCFRRLLLI 4010 RSWCPDRTIA 4020 QARKYIVDSM 4030 GEKYAEGVIL 4040 DLEKTWEESD 4050 PRTPLICLLS 4060 MGSDPTDSII 4070 ALGKRLKIET 4080 RYVSMGQGQE 4090 VHARKLLQQT 4100 MANGGWALLQ 4110 NCHLGLDFMD 4120 ELMDIIIETE 4130 LVHDAFRLWM 4140 TTEAHKQFPI 4150 TLLQMSIKFA 4160 NDPPQGLRAG 4170 LKRTYSGVSQ 4180 DLLDVSSGSQ 4190 WKPMLYAVAF 4200 LHSTVQERRK 4210 FGALGWNIPY 4220 EFNQADFNAT 4230 VQFIQNHLDD 4240 MDVKKGVSWT 4250 TIRYMIGEIQ 4260 YGGRVTDDYD 4270 KRLLNTFAKV 4280 WFSENMFGPD 4290 FSFYQGYNIP 4300 KCSTVDNYLQ 4310 YIQSLPAYDS 4320 PEVFGLHPNA 4330 DITYQSKLAK 4340 DVLDTILGIQ 4350 PKDTSGGGDE 4360 TREAVVARLA 4370 DDMLEKLPPD 4380 YVPFEVKERL 4390 QKMGPFQPMN 4400 IFLRQEIDRM 4410 QRVLSLVRST 4420 LTELKLAIDG 4430 TIIMSENLRD 4440 ALDCMFDARI 4450 PAWWKKASWI 4460 SSTLGFWFTE 4470 LIERNSQFTS 4480 WVFNGRPHCF 4490 WMTGFFNPQG 4500 FLTAMRQEIT 4510 RANKGWALDN 4520 MVLCNEVTKW 4530 MKDDISAPPT 4540 EGVYVYGLYL 4550 EGAGWDKRNM 4560 KLIESKPKVL 4570 FELMPVIRIY 4580 AENNTLRDPR 4590 FYSCPIYKKP 4600 VRTDLNYIAA 4610 VDLRTAQTPE 4620 HWVLRGVALL CDVK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0097728 9+0 motile cilium
Cellular Component GO:0097729 9+2 motile cilium
Cellular Component GO:0005930 axoneme
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005874 microtubule
Cellular Component GO:0031514 motile cilium
Cellular Component GO:0036157 outer dynein arm
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0045505 dynein intermediate chain binding
Molecular Function GO:0051959 dynein light intermediate chain binding
Molecular Function GO:0008569 minus-end-directed microtubule motor activity
Biological Process GO:0060271 cilium assembly
Biological Process GO:0003341 cilium movement
Biological Process GO:0060294 cilium movement involved in cell motility
Biological Process GO:0007368 determination of left/right symmetry
Biological Process GO:0030317 flagellated sperm motility
Biological Process GO:0036158 outer dynein arm assembly

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.