Search Results

Overview

Uniprot IDQ8TE76
Protein NameMORC family CW-type zinc finger protein 4
Gene NameMORC4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
113 FTDKVIKKSQCPIGV
575 LGEEPVEKRRRLQNE
650 SILYPGAKDQRQGSL
764 GHNTPKLKNQRELEE

Function

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034)

Protein Sequence

10 MLLYRGAPAG 20 PGAPGCGLAR 30 PGGGPQAFGI 40 RLSTMSPRYL 50 QSNSSSHTRP 60 FSAIAELLDN 70 AVDPDVSART 80 VFIDVEEVKN 90 KSCLTFTDDG 100 CGMTPHKLHR 110 MLSFGFTDKV 120 IKKSQCPIGV 130 FGNGFKSGSM 140 RLGKDALVFT 150 KNGGTLTVGL 160 LSQTYLECVQ 170 AQAVIVPIVP 180 FNQQNKKMII 190 TEDSLPSLEA 200 ILNYSIFNRE 210 NDLLAQFDAI 220 PGKKGTRVLI 230 WNIRRNKNGK 240 SELDFDTDQY 250 DILVSDFDTE 260 EKMTGGVTSE 270 LPETEYSLRA 280 FCGILYMKPR 290 MKIFLRQKKV 300 TTQMIAKSLA 310 NVEYDTYKPT 320 FTNKQVRITF 330 GFSCKNSNQF 340 GIMMYHNNRL 350 IKSFEKVGCQ 360 VKPTRGEGVG 370 VIGVIECNFL 380 KPAYNKQDFE 390 YTKEYRLTIN 400 ALAQKLNAYW 410 KEKTSQDNFE 420 TSTVARPIPK 430 VPDQTWVQCD 440 ECLKWRKLPG 450 KIDPSMLPAR 460 WFCYYNSHPK 470 YRRCSVPEEQ 480 ELTDEDLCLS 490 KAKKQEQTVE 500 EKKKMPMENE 510 NHQVFSNPPK 520 ILTVQEMAGL 530 NNKTIGYEGI 540 HSPSVLPSGG 550 EESRSPSLQL 560 KPLDSSVLQF 570 SSKYKWILGE 580 EPVEKRRRLQ 590 NEMTTPSLDY 600 SMPAPYRRVE 610 APVAYPEGEN 620 SHDKSSSERS 630 TPPYLFPEYP 640 EASKNTGQNR 650 EVSILYPGAK 660 DQRQGSLLPE 670 ELEDQMPRLV 680 AEESNRGSTT 690 INKEEVNKGP 700 FVAVVGVAKG 710 VRDSGAPIQL 720 IPFNREELAE 730 RRKAVESWNP 740 VPYSVASAAI 750 PAAAIGEKAR 760 GYEESEGHNT 770 PKLKNQRELE 780 ELKRTTEKLE 790 RVLAERNLFQ 800 QKVEELEQER 810 NHWQSEFKKV 820 QHELVIYSTQ 830 EAEGLYWSKK 840 HMGYRQAEFQ 850 ILKAELERTK 860 EEKQELKEKL 870 KETETHLEML 880 QKAQVSYRTP 890 EGDDLERALA 900 KLTRLRIHVS 910 YLLTSVLPHL 920 ELREIGYDSE 930 QVDGILYTVL EANHILD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0140002 histone H3K4me3 reader activity
Molecular Function GO:0008270 zinc ion binding

Reference

PMID: N/A