Search Results
Overview
| Uniprot ID | Q8TE77 |
|---|---|
| Protein Name | Protein phosphatase Slingshot homolog 3 |
| Gene Name | SSH3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 584 | FPQLARTKGGQQVDR |
| 598 | RGPQPALKSRQSVVT |
Function
Protein phosphatase which may play a role in the regulation of actin filament dynamics. Can dephosphorylate and activate the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly (By similarity)
Protein Sequence
10
MALVTVSRSP
20
PGSGASTPVG
30
PWDQAVQRRS
40
RLQRRQSFAV
50
LRGAVLGLQD
60
GGDNDDAAEA
70
SSEPTEKAPS
80
EEELHGDQTD
90
FGQGSQSPQK
100
QEEQRQHLHL
110
MVQLLRPQDD
120
IRLAAQLEAP
130
RPPRLRYLLV
140
VSTREGEGLS
150
QDETVLLGVD
160
FPDSSSPSCT
170
LGLVLPLWSD
180
TQVYLDGDGG
190
FSVTSGGQSR
200
IFKPISIQTM
210
WATLQVLHQA
220
CEAALGSGLV
230
PGGSALTWAS
240
HYQERLNSEQ
250
SCLNEWTAMA
260
DLESLRPPSA
270
EPGGSSEQEQ
280
MEQAIRAELW
290
KVLDVSDLES
300
VTSKEIRQAL
310
ELRLGLPLQQ
320
YRDFIDNQML
330
LLVAQRDRAS
340
RIFPHLYLGS
350
EWNAANLEEL
360
QRNRVTHILN
370
MAREIDNFYP
380
ERFTYHNVRL
390
WDEESAQLLP
400
HWKETHRFIE
410
AARAQGTHVL
420
VHCKMGVSRS
430
AATVLAYAMK
440
QYECSLEQAL
450
RHVQELRPIA
460
RPNPGFLRQL
470
QIYQGILTAS
480
RQSHVWEQKV
490
GGVSPEEHPA
500
PEVSTPFPPL
510
PPEPEGGGEE
520
KVVGMEESQA
530
APKEEPGPRP
540
RINLRGVMRS
550
ISLLEPSLEL
560
ESTSETSDMP
570
EVFSSHESSH
580
EEPLQPFPQL
590
ARTKGGQQVD
600
RGPQPALKSR
610
QSVVTLQGSA
620
VVANRTQAFQ
630
EQEQGQGQGQ
640
GEPCISSTPR
650
FRKVVRQASV
HDSGEEGEA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003779 | actin binding |
| Molecular Function | GO:0004721 | phosphoprotein phosphatase activity |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Biological Process | GO:0030036 | actin cytoskeleton organization |
| Biological Process | GO:0030837 | negative regulation of actin filament polymerization |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.