Search Results

Overview

Uniprot IDQ8TEA8
Protein NameD-aminoacyl-tRNA deacylase 1
Gene NameDTD1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
162 SDPKQLSKLEKQQQR
165 KQLSKLEKQQQRKEK
176 RKEKTRAKGPSESSK
190 KERNTPRKEDRSASS

Function

Possible ATPase (PubMed:15653697) involved in DNA replication, may facilitate loading of CDC45 onto pre-replication complexes (PubMed:20065034)

Protein Sequence

10 MKAVVQRVTR 20 ASVTVGGEQI 30 SAIGRGICVL 40 LGISLEDTQK 50 ELEHMVRKIL 60 NLRVFEDESG 70 KHWSKSVMDK 80 QYEILCVSQF 90 TLQCVLKGNK 100 PDFHLAMPTE 110 QAEGFYNSFL 120 EQLRKTYRPE 130 LIKDGKFGAY 140 MQVHIQNDGP 150 VTIELESPAP 160 GTATSDPKQL 170 SKLEKQQQRK 180 EKTRAKGPSE 190 SSKERNTPRK 200 EDRSASSGAE GDVSSEREP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Molecular Function GO:0051500 D-tyrosyl-tRNA(Tyr) deacylase activity
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0106026 Gly-tRNA(Ala) deacylase activity
Molecular Function GO:0046872 metal ion binding
Molecular Function GO:0000049 tRNA binding
Biological Process GO:0006260 DNA replication
Biological Process GO:0006399 tRNA metabolic process

Reference

[1] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.