Search Results

Overview

Uniprot IDQ8TEH3
Protein NameDENN domain-containing protein 1A
Gene NameDENND1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
723 PPIPRPAKLQAAGAA

Function

Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity)

Protein Sequence

10 MGSRIKQNPE 20 TTFEVYVEVA 30 YPRTGGTLSD 40 PEVQRQFPED 50 YSDQEVLQTL 60 TKFCFPFYVD 70 SLTVSQVGQN 80 FTFVLTDIDS 90 KQRFGFCRLS 100 SGAKSCFCIL 110 SYLPWFEVFY 120 KLLNILADYT 130 TKRQENQWNE 140 LLETLHKLPI 150 PDPGVSVHLS 160 VHSYFTVPDT 170 RELPSIPENR 180 NLTEYFVAVD 190 VNNMLHLYAS 200 MLYERRILII 210 CSKLSTLTAC 220 IHGSAAMLYP 230 MYWQHVYIPV 240 LPPHLLDYCC 250 APMPYLIGIH 260 LSLMEKVRNM 270 ALDDVVILNV 280 DTNTLETPFD 290 DLQSLPNDVI 300 SSLKNRLKKV 310 STTTGDGVAR 320 AFLKAQAAFF 330 GSYRNALKIE 340 PEEPITFCEE 350 AFVSHYRSGA 360 MRQFLQNATQ 370 LQLFKQFIDG 380 RLDLLNSGEG 390 FSDVFEEEIN 400 MGEYAGSDKL 410 YHQWLSTVRK 420 GSGAILNTVK 430 TKANPAMKTV 440 YKFAKDHAKM 450 GIKEVKNRLK 460 QKDIAENGCA 470 PTPEEQLPKT 480 APSPLVEAKD 490 PKLREDRRPI 500 TVHFGQVRPP 510 RPHVVKRPKS 520 NIAVEGRRTS 530 VPSPEQPQPY 540 RTLRESDSAE 550 GDEAESPEQQ 560 VRKSTGPVPA 570 PPDRAASIDL 580 LEDVFSNLDM 590 EAALQPLGQA 600 KSLEDLRAPK 610 DLREQPGTFD 620 YQRLDLGGSE 630 RSRGVTVALK 640 LTHPYNKLWS 650 LGQDDMAIPS 660 KPPAASPEKP 670 SALLGNSLAL 680 PRRPQNRDSI 690 LNPSDKEEVP 700 TPTLGSITIP 710 RPQGRKTPEL 720 GIVPPPPIPR 730 PAKLQAAGAA 740 LGDVSERLQT 750 DRDRRAALSP 760 GLLPGVVPQG 770 PTELLQPLSP 780 GPGAAGTSSD 790 ALLALLDPLS 800 TAWSGSTLPS 810 RPATPNVATP 820 FTPQFSFPPA 830 GTPTPFPQPP 840 LNPFVPSMPA 850 APPTLPLVST 860 PAGPFGAPPA 870 SLGPAFASGL 880 LLSSAGFCAP 890 HRSQPNLSAL 900 SMPNLFGQMP 910 MGTHTSPLQP 920 LGPPAVAPSR 930 IRTLPLARSS 940 ARAAETKQGL 950 ALRPGDPPLL 960 PPRPPQGLEP 970 TLQPSAPQQA 980 RDPFEDLLQK 990 TKQDVSPSPA 1000 LAPAPDSVEQ LRKQWETFE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0030136 clathrin-coated vesicle
Cellular Component GO:0030665 clathrin-coated vesicle membrane
Cellular Component GO:0005829 cytosol
Cellular Component GO:0042734 presynaptic membrane
Molecular Function GO:0005085 guanyl-nucleotide exchange factor activity
Molecular Function GO:1901981 phosphatidylinositol phosphate binding
Molecular Function GO:0032266 phosphatidylinositol-3-phosphate binding
Biological Process GO:0032456 endocytic recycling
Biological Process GO:0006897 endocytosis
Biological Process GO:0015031 protein transport
Biological Process GO:0032483 regulation of Rab protein signal transduction

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.