Search Results

Overview

Uniprot IDQ8TEK3
Protein NameHistone-lysine N-methyltransferase, H3 lysine-79 specific
Gene NameDOT1L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
330 ENYFSSLKNPKLREE
333 FSSLKNPKLREEQEA
762 VGRPRLEKLSGLAAP

Function

Histone methyltransferase that methylates 'Lys-79' of histone H3 (PubMed:12123582, PubMed:38503750, PubMed:38129415). Histones in nucleosomes are preferred as substrate compared to free histones (PubMed:12123582, PubMed:38503750). Binds to DNA (PubMed:12628190, PubMed:38503750). Together with MLLT3/AF9, is involved in SCNN1A transcriptional repression following H3K79 hypermethylation at the promoter (By similarity)

Protein Sequence

10 MGEKLELRLK 20 SPVGAEPAVY 30 PWPLPVYDKH 40 HDAAHEIIET 50 IRWVCEEIPD 60 LKLAMENYVL 70 IDYDTKSFES 80 MQRLCDKYNR 90 AIDSIHQLWK 100 GTTQPMKLNT 110 RPSTGLLRHI 120 LQQVYNHSVT 130 DPEKLNNYEP 140 FSPEVYGETS 150 FDLVAQMIDE 160 IKMTDDDLFV 170 DLGSGVGQVV 180 LQVAAATNCK 190 HHYGVEKADI 200 PAKYAETMDR 210 EFRKWMKWYG 220 KKHAEYTLER 230 GDFLSEEWRE 240 RIANTSVIFV 250 NNFAFGPEVD 260 HQLKERFANM 270 KEGGRIVSSK 280 PFAPLNFRIN 290 SRNLSDIGTI 300 MRVVELSPLK 310 GSVSWTGKPV 320 SYYLHTIDRT 330 ILENYFSSLK 340 NPKLREEQEA 350 ARRRQQRESK 360 SNAATPTKGP 370 EGKVAGPADA 380 PMDSGAEEEK 390 AGAATVKKPS 400 PSKARKKKLN 410 KKGRKMAGRK 420 RGRPKKMNTA 430 NPERKPKKNQ 440 TALDALHAQT 450 VSQTAASSPQ 460 DAYRSPHSPF 470 YQLPPSVQRH 480 SPNPLLVAPT 490 PPALQKLLES 500 FKIQYLQFLA 510 YTKTPQYKAS 520 LQELLGQEKE 530 KNAQLLGAAQ 540 QLLSHCQAQK 550 EEIRRLFQQK 560 LDELGVKALT 570 YNDLIQAQKE 580 ISAHNQQLRE 590 QSEQLEQDNR 600 ALRGQSLQLL 610 KARCEELQLD 620 WATLSLEKLL 630 KEKQALKSQI 640 SEKQRHCLEL 650 QISIVELEKS 660 QRQQELLQLK 670 SCVPPDDALS 680 LHLRGKGALG 690 RELEPDASRL 700 HLELDCTKFS 710 LPHLSSMSPE 720 LSMNGQAAGY 730 ELCGVLSRPS 740 SKQNTPQYLA 750 SPLDQEVVPC 760 TPSHVGRPRL 770 EKLSGLAAPD 780 YTRLSPAKIV 790 LRRHLSQDHT 800 VPGRPAASEL 810 HSRAEHTKEN 820 GLPYQSPSVP 830 GSMKLSPQDP 840 RPLSPGALQL 850 AGEKSSEKGL 860 RERAYGSSGE 870 LITSLPISIP 880 LSTVQPNKLP 890 VSIPLASVVL 900 PSRAERARST 910 PSPVLQPRDP 920 SSTLEKQIGA 930 NAHGAGSRSL 940 ALAPAGFSYA 950 GSVAISGALA 960 GSPASLTPGA 970 EPATLDESSS 980 SGSLFATVGS 990 RSSTPQHPLL 1000 LAQPRNSLPA 1010 SPAHQLSSSP 1020 RLGGAAQGPL 1030 PEASKGDLPS 1040 DSGFSDPESE 1050 AKRRIVFTIT 1060 TGAGSAKQSP 1070 SSKHSPLTAS 1080 ARGDCVPSHG 1090 QDSRRRGRRK 1100 RASAGTPSLS 1110 AGVSPKRRAL 1120 PSVAGLFTQP 1130 SGSPLNLNSM 1140 VSNINQPLEI 1150 TAISSPETSL 1160 KSSPVPYQDH 1170 DQPPVLKKER 1180 PLSQTNGAHY 1190 SPLTSDEEPG 1200 SEDEPSSARI 1210 ERKIATISLE 1220 SKSPPKTLEN 1230 GGGLAGRKPA 1240 PAGEPVNSSK 1250 WKSTFSPISD 1260 IGLAKSADSP 1270 LQASSALSQN 1280 SLFTFRPALE 1290 EPSADAKLAA 1300 HPRKGFPGSL 1310 SGADGLSPGT 1320 NPANGCTFGG 1330 GLAADLSLHS 1340 FSDGASLPHK 1350 GPEAAGLSSP 1360 LSFPSQRGKE 1370 GSDANPFLSK 1380 RQLDGLAGLK 1390 GEGSRGKEAG 1400 EGGLPLCGPT 1410 DKTPLLSGKA 1420 AKARDREVDL 1430 KNGHNLFISA 1440 AAVPPGSLLS 1450 GPGLAPAASS 1460 AGGAASSAQT 1470 HRSFLGPFPP 1480 GPQFALGPMS 1490 LQANLGSVAG 1500 SSVLQSLFSS 1510 VPAAAGLVHV 1520 SSAATRLTNS 1530 HAMGSFSGVA GGTVGGN

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000781 chromosome, telomeric region
Molecular Function GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0000077 DNA damage checkpoint signaling
Biological Process GO:0006281 DNA repair
Biological Process GO:0032259 methylation
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0046425 regulation of receptor signaling pathway via JAK-STAT
Biological Process GO:2000677 regulation of transcription regulatory region DNA binding
Biological Process GO:0031509 subtelomeric heterochromatin formation
Biological Process GO:0032200 telomere organization
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0140938 histone H3 methyltransferase activity
Molecular Function GO:0031151 histone H3K79 methyltransferase activity
Molecular Function GO:0140956 histone H3K79 trimethyltransferase activity
Molecular Function GO:0042054 histone methyltransferase activity
Molecular Function GO:0003676 nucleic acid binding

Reference

PMID: N/A