Search Results
Overview
| Uniprot ID | Q8TEW0 |
|---|---|
| Protein Name | Partitioning defective 3 homolog |
| Gene Name | PARD3 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 611 | SVKGNRSKENHADLG |
| 686 | IVARRISKCNELKSP |
Function
Adapter protein involved in asymmetrical cell division and cell polarization processes (PubMed:10954424, PubMed:27925688). Seems to play a central role in the formation of epithelial tight junctions (PubMed:27925688). Targets the phosphatase PTEN to cell junctions (By similarity). Involved in Schwann cell peripheral myelination (By similarity). Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly (By similarity). The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins (PubMed:10934474). Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (PubMed:19812038, PubMed:27925688)
Protein Sequence
10
MKVTVCFGRT
20
RVVVPCGDGH
30
MKVFSLIQQA
40
VTRYRKAIAK
50
DPNYWIQVHR
60
LEHGDGGILD
70
LDDILCDVAD
80
DKDRLVAVFD
90
EQDPHHGGDG
100
TSASSTGTQS
110
PEIFGSELGT
120
NNVSAFQPYQ
130
ATSEIEVTPS
140
VLRANMPLHV
150
RRSSDPALIG
160
LSTSVSDSNF
170
SSEEPSRKNP
180
TRWSTTAGFL
190
KQNTAGSPKT
200
CDRKKDENYR
210
SLPRDTSNWS
220
NQFQRDNARS
230
SLSASHPMVG
240
KWLEKQEQDE
250
DGTEEDNSRV
260
EPVGHADTGL
270
EHIPNFSLDD
280
MVKLVEVPND
290
GGPLGIHVVP
300
FSARGGRTLG
310
LLVKRLEKGG
320
KAEHENLFRE
330
NDCIVRINDG
340
DLRNRRFEQA
350
QHMFRQAMRT
360
PIIWFHVVPA
370
ANKEQYEQLS
380
QSEKNNYYSS
390
RFSPDSQYID
400
NRSVNSAGLH
410
TVQRAPRLNH
420
PPEQIDSHSR
430
LPHSAHPSGK
440
PPSAPASAPQ
450
NVFSTTVSSG
460
YNTKKIGKRL
470
NIQLKKGTEG
480
LGFSITSRDV
490
TIGGSAPIYV
500
KNILPRGAAI
510
QDGRLKAGDR
520
LIEVNGVDLV
530
GKSQEEVVSL
540
LRSTKMEGTV
550
SLLVFRQEDA
560
FHPRELNAEP
570
SQMQIPKETK
580
AEDEDIVLTP
590
DGTREFLTFE
600
VPLNDSGSAG
610
LGVSVKGNRS
620
KENHADLGIF
630
VKSIINGGAA
640
SKDGRLRVND
650
QLIAVNGESL
660
LGKTNQDAME
670
TLRRSMSTEG
680
NKRGMIQLIV
690
ARRISKCNEL
700
KSPGSPPGPE
710
LPIETALDDR
720
ERRISHSLYS
730
GIEGLDESPS
740
RNAALSRIMG
750
ESGKYQLSPT
760
VNMPQDDTVI
770
IEDDRLPVLP
780
PHLSDQSSSS
790
SHDDVGFVTA
800
DAGTWAKAAI
810
SDSADCSLSP
820
DVDPVLAFQR
830
EGFGRQSMSE
840
KRTKQFSDAS
850
QLDFVKTRKS
860
KSMDLGIADE
870
TKLNTVDDQK
880
AGSPSRDVGP
890
SLGLKKSSSL
900
ESLQTAVAEV
910
TLNGDIPFHR
920
PRPRIIRGRG
930
CNESFRAAID
940
KSYDKPAVDD
950
DDEGMETLEE
960
DTEESSRSGR
970
ESVSTASDQP
980
SHSLERQMNG
990
NQEKGDKTDR
1000
KKDKTGKEKK
1010
KDRDKEKDKM
1020
KAKKGMLKGL
1030
GDMFRFGKHR
1040
KDDKIEKTGK
1050
IKIQESFTSE
1060
EERIRMKQEQ
1070
ERIQAKTREF
1080
RERQARERDY
1090
AEIQDFHRTF
1100
GCDDELMYGG
1110
VSSYEGSMAL
1120
NARPQSPREG
1130
HMMDALYAQV
1140
KKPRNSKPSP
1150
VDSNRSTPSN
1160
HDRIQRLRQE
1170
FQQAKQDEDV
1180
EDRRRTYSFE
1190
QPWPNARPAT
1200
QSGRHSVSVE
1210
VQMQRQRQEE
1220
RESSQQAQRQ
1230
YSSLPRQSRK
1240
NASSVSQDSW
1250
EQNYSPGEGF
1260
QSAKENPRYS
1270
SYQGSRNGYL
1280
GGHGFNARVM
1290
LETQELLRQE
1300
QRRKEQQMKK
1310
QPPSEGPSNY
1320
DSYKKVQDPS
1330
YAPPKGPFRQ
1340
DVPPSPSQVA
1350
RLNRLQTPEK
GRPFYS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005912 | adherens junction |
| Cellular Component | GO:0043296 | apical junction complex |
| Cellular Component | GO:0016324 | apical plasma membrane |
| Cellular Component | GO:0005923 | bicellular tight junction |
| Cellular Component | GO:0005938 | cell cortex |
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0005911 | cell-cell junction |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0012505 | endomembrane system |
| Cellular Component | GO:0033269 | internode region of axon |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0070160 | tight junction |
| Molecular Function | GO:0035091 | phosphatidylinositol binding |
| Molecular Function | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding |
| Molecular Function | GO:0032266 | phosphatidylinositol-3-phosphate binding |
| Molecular Function | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding |
| Biological Process | GO:0008356 | asymmetric cell division |
| Biological Process | GO:0007409 | axonogenesis |
| Biological Process | GO:0070830 | bicellular tight junction assembly |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0030010 | establishment of cell polarity |
| Biological Process | GO:0090162 | establishment of epithelial cell polarity |
| Biological Process | GO:0007163 | establishment or maintenance of cell polarity |
| Biological Process | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity |
| Biological Process | GO:0008104 | intracellular protein localization |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0022011 | myelination in peripheral nervous system |
| Biological Process | GO:0010801 | negative regulation of peptidyl-threonine phosphorylation |
| Biological Process | GO:0007200 | phospholipase C-activating G protein-coupled receptor signaling pathway |
| Biological Process | GO:0031643 | positive regulation of myelination |
| Biological Process | GO:0006612 | protein targeting to membrane |
| Biological Process | GO:0065003 | protein-containing complex assembly |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.