Search Results

Overview

Uniprot IDQ8TEX9
Protein NameImportin-4
Gene NameIPO4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
867 PLLVCKTKQGCTVAE

Function

Nuclear transport receptor that mediates nuclear import of proteins, such as histones, RPS3A, TNP2 and VDR (PubMed:11823430, PubMed:16207705, PubMed:17682055, PubMed:21454524, PubMed:30177573). Serves as receptor for nuclear localization signals (NLS) in cargo substrates (PubMed:11823430, PubMed:16207705). Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:11823430, PubMed:16207705). At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran (PubMed:11823430). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:11823430). Mediates the nuclear import of the histone H3-H4 dimer when in complex with ASF1 (ASF1A or ASF1B) (PubMed:21454524, PubMed:29408485, PubMed:36103578). Also mediates the nuclear import of monomeric histones H3.1 and H4 (PubMed:30177573). Mediates the ligand-independent nuclear import of vitamin D receptor (VDR) (PubMed:16207705). In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS (PubMed:12610148)

Protein Sequence

10 MESAGLEQLL 20 RELLLPDTER 30 IRRATEQLQI 40 VLRAPAALPA 50 LCDLLASAAD 60 PQIRQFAAVL 70 TRRRLNTRWR 80 RLAAEQRESL 90 KSLILTALQR 100 ETEHCVSLSL 110 AQLSATIFRK 120 EGLEAWPQLL 130 QLLQHSTHSP 140 HSPEREMGLL 150 LLSVVVTSRP 160 EAFQPHHREL 170 LRLLNETLGE 180 VGSPGLLFYS 190 LRTLTTMAPY 200 LSTEDVPLAR 210 MLVPKLIMAM 220 QTLIPIDEAK 230 ACEALEALDE 240 LLESEVPVIT 250 PYLSEVLTFC 260 LEVARNVALG 270 NAIRIRILCC 280 LTFLVKVKSK 290 ALLKNRLLPP 300 LLHTLFPIVA 310 AEPPPGQLDP 320 EDQDSEEEEL 330 EIELMGETPK 340 HFAVQVVDML 350 ALHLPPEKLC 360 PQLMPMLEEA 370 LRSESPYQRK 380 AGLLVLAVLS 390 DGAGDHIRQR 400 LLPPLLQIVC 410 KGLEDPSQVV 420 RNAALFALGQ 430 FSENLQPHIS 440 SYSREVMPLL 450 LAYLKSVPLG 460 HTHHLAKACY 470 ALENFVENLG 480 PKVQPYLPEL 490 MECMLQLLRN 500 PSSPRAKELA 510 VSALGAIATA 520 AQASLLPYFP 530 AIMEHLREFL 540 LTGREDLQPV 550 QIQSLETLGV 560 LARAVGEPMR 570 PLAEECCQLG 580 LGLCDQVDDP 590 DLRRCTYSLF 600 AALSGLMGEG 610 LAPHLEQITT 620 LMLLSLRSTE 630 GIVPQYDGSS 640 SFLLFDDESD 650 GEEEEELMDE 660 DVEEEDDSEI 670 SGYSVENAFF 680 DEKEDTCAAV 690 GEISVNTSVA 700 FLPYMESVFE 710 EVFKLLECPH 720 LNVRKAAHEA 730 LGQFCCALHK 740 ACQSCPSEPN 750 TAALQAALAR 760 VVPSYMQAVN 770 RERERQVVMA 780 VLEALTGVLR 790 SCGTLTLKPP 800 GRLAELCGVL 810 KAVLQRKTAC 820 QDTDEEEEEE 830 DDDQAEYDAM 840 LLEHAGEAIP 850 ALAAAAGGDS 860 FAPFFAGFLP 870 LLVCKTKQGC 880 TVAEKSFAVG 890 TLAETIQGLG 900 AASAQFVSRL 910 LPVLLSTAQE 920 ADPEVRSNAI 930 FGMGVLAEHG 940 GHPAQEHFPK 950 LLGLLFPLLA 960 RERHDRVRDN 970 ICGALARLLM 980 ASPTRKPEPQ 990 VLAALLHALP 1000 LKEDLEEWVT 1010 IGRLFSFLYQ 1020 SSPDQVIDVA 1030 PELLRICSLI 1040 LADNKIPPDT 1050 KAALLLLLTF 1060 LAKQHTDSFQ 1070 AALGSLPVDK 1080 AQELQAVLGL S

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0061608 nuclear import signal receptor activity
Molecular Function GO:0008139 nuclear localization sequence binding
Molecular Function GO:0031267 small GTPase binding
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0034504 protein localization to nucleus

Reference

[1] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.