Search Results
Overview
| Uniprot ID | Q8TF42 |
|---|---|
| Protein Name | Ubiquitin-associated and SH3 domain-containing protein B |
| Gene Name | UBASH3B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 21 | AREELYSKVTPRRNR |
Function
Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination
Protein Sequence
10
MAQYGHPSPL
20
GMAAREELYS
30
KVTPRRNRQQ
40
RPGTIKHGSA
50
LDVLLSMGFP
60
RARAQKALAS
70
TGGRSVQAAC
80
DWLFSHVGDP
90
FLDDPLPREY
100
VLYLRPTGPL
110
AQKLSDFWQQ
120
SKQICGKNKA
130
HNIFPHITLC
140
QFFMCEDSKV
150
DALGEALQTT
160
VSRWKCKFSA
170
PLPLELYTSS
180
NFIGLFVKED
190
SAEVLKKFAA
200
DFAAEAASKT
210
EVHVEPHKKQ
220
LHVTLAYHFQ
230
ASHLPTLEKL
240
AQNIDVKLGC
250
DWVATIFSRD
260
IRFANHETLQ
270
VIYPYTPQND
280
DELELVPGDF
290
IFMSPMEQTS
300
TSEGWIYGTS
310
LTTGCSGLLP
320
ENYITKADEC
330
STWIFHGSYS
340
ILNTSSSNSL
350
TFGDGVLERR
360
PYEDQGLGET
370
TPLTIICQPM
380
QPLRVNSQPG
390
PQKRCLFVCR
400
HGERMDVVFG
410
KYWLSQCFDA
420
KGRYIRTNLN
430
MPHSLPQRSG
440
GFRDYEKDAP
450
ITVFGCMQAR
460
LVGEALLESN
470
TIIDHVYCSP
480
SLRCVQTAHN
490
ILKGLQQENH
500
LKIRVEPGLF
510
EWTKWVAGST
520
LPAWIPPSEL
530
AAANLSVDTT
540
YRPHIPISKL
550
VVSESYDTYI
560
SRSFQVTKEI
570
ISECKSKGNN
580
ILIVAHASSL
590
EACTCQLQGL
600
SPQNSKDFVQ
610
MVRKIPYLGF
620
CSCEELGETG
630
IWQLTDPPIL
640
PLTHGPTGGF
NWRETLLQE
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0051219 | phosphoprotein binding |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0038063 | collagen-activated tyrosine kinase receptor signaling pathway |
| Biological Process | GO:0045779 | negative regulation of bone resorption |
| Biological Process | GO:0009968 | negative regulation of signal transduction |
| Biological Process | GO:0070527 | platelet aggregation |
| Biological Process | GO:0045670 | regulation of osteoclast differentiation |
| Biological Process | GO:0051279 | regulation of release of sequestered calcium ion into cytosol |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.