Search Results

Overview

Uniprot IDQ8TF46
Protein NameDIS3-like exonuclease 1
Gene NameDIS3L
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
975 RLEIISNKPYKIPNT

Function

Catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events (PubMed:20531386, PubMed:20531389, PubMed:37602378). In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA (PubMed:20531386, PubMed:20531389)

Protein Sequence

10 MLQKREKVLL 20 LRTFQGRTLR 30 IVREHYLRPC 40 VPCHSPLCPQ 50 PAACSHDGKL 60 LSSDVTHYVI 70 PDWKVVQDYL 80 EILEFPELKG 90 IIFMQTACQA 100 VQHQRGRRQY 110 NKLRNLLKDA 120 RHDCILFANE 130 FQQCCYLPRE 140 RGESMEKWQT 150 RSIYNAAVWY 160 YHHCQDRMPI 170 VMVTEDEEAI 180 QQYGSETEGV 190 FVITFKNYLD 200 NFWPDLKAAH 210 ELCDSILQSR 220 RERENESQES 230 HGKEYPEHLP 240 LEVLEAGIKS 250 GRYIQGILNV 260 NKHRAQIEAF 270 VRLQGASSKD 280 SDLVSDILIH 290 GMKARNRSIH 300 GDVVVVELLP 310 KNEWKGRTVA 320 LCENDCDDKA 330 SGESPSEPMP 340 TGRVVGILQK 350 NWRDYVVTFP 360 SKEEVQSQGK 370 NAQKILVTPW 380 DYRIPKIRIS 390 TQQAETLQDF 400 RVVVRIDSWE 410 STSVYPNGHF 420 VRVLGRIGDL 430 EGEIATILVE 440 NSISVIPFSE 450 AQMCEMPVNT 460 PESPWKVSPE 470 EEQKRKDLRK 480 SHLVFSIDPK 490 GCEDVDDTLS 500 VRTLNNGNLE 510 LGVHIADVTH 520 FVAPNSYIDI 530 EARTRATTYY 540 LADRRYDMLP 550 SVLSADLCSL 560 LGGVDRYAVS 570 IMWELDKASY 580 EIKKVWYGRT 590 IIRSAYKLFY 600 EAAQELLDGN 610 LSVVDDIPEF 620 KDLDEKSRQA 630 KLEELVWAIG 640 KLTDIARHVR 650 AKRDGCGALE 660 LEGVEVCVQL 670 DDKKNIHDLI 680 PKQPLEVHET 690 VAECMILANH 700 WVAKKIWESF 710 PHQALLRQHP 720 PPHQEFFSEL 730 RECAKAKGFF 740 IDTRSNKTLA 750 DSLDNANDPH 760 DPIVNRLLRS 770 MATQAMSNAL 780 YFSTGSCAEE 790 EFHHYGLALD 800 KYTHFTSPIR 810 RYSDIVVHRL 820 LMAAISKDKK 830 MEIKGNLFSN 840 KDLEELCRHI 850 NNRNQAAQHS 860 QKQSTELFQC 870 MYFKDKDPAT 880 EERCISDGVI 890 YSIRTNGVLL 900 FIPRFGIKGA 910 AYLKNKDGLV 920 ISCGPDSCSE 930 WKPGSLQRFQ 940 NKITSTTTDG 950 ESVTFHLFDH 960 VTVRISIQAS 970 RCHSDTIRLE 980 IISNKPYKIP 990 NTELIHQSSP 1000 LLKSELVKEV 1010 TKSVEEAQLA 1020 QEVKVNIIQE 1030 EYQEYRQTKG 1040 RSLYTLLEEI 1050 RDLALLDVSN NYGI

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000177 cytoplasmic exosome (RNase complex)
Cellular Component GO:0005829 cytosol
Molecular Function GO:0000175 3'-5'-RNA exonuclease activity
Molecular Function GO:0019899 enzyme binding
Molecular Function GO:0008859 exoribonuclease II activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0006402 mRNA catabolic process
Biological Process GO:0006401 RNA catabolic process
Biological Process GO:0006396 RNA processing
Biological Process GO:0016075 rRNA catabolic process

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.