Search Results

Overview

Uniprot IDQ8TF72
Protein NameProtein Shroom3
Gene NameSHROOM3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1576 PSFNKLSKVTIARER

Function

Controls cell shape changes in the neuroepithelium during neural tube closure. Induces apical constriction in epithelial cells by promoting the apical accumulation of F-actin and myosin II, and probably by bundling stress fibers (By similarity). Induces apicobasal cell elongation by redistributing gamma-tubulin and directing the assembly of robust apicobasal microtubule arrays (By similarity)

Protein Sequence

10 MMRTTEDFHK 20 PSATLNSNTA 30 TKGRYIYLEA 40 FLEGGAPWGF 50 TLKGGLEHGE 60 PLIISKVEEG 70 GKADTLSSKL 80 QAGDEVVHIN 90 EVTLSSSRKE 100 AVSLVKGSYK 110 TLRLVVRRDV 120 CTDPGHADTG 130 ASNFVSPEHL 140 TSGPQHRKAA 150 WSGGVKLRLK 160 HRRSEPAGRP 170 HSWHTTKSGE 180 KQPDASMMQI 190 SQGMIGPPWH 200 QSYHSSSSTS 210 DLSNYDHAYL 220 RRSPDQCSSQ 230 GSMESLEPSG 240 AYPPCHLSPA 250 KSTGSIDQLS 260 HFHNKRDSAY 270 SSFSTSSSIL 280 EYPHPGISGR 290 ERSGSMDNTS 300 ARGGLLEGMR 310 QADIRYVKTV 320 YDTRRGVSAE 330 YEVNSSALLL 340 QGREARASAN 350 GQGYDKWSNI 360 PRGKGVPPPS 370 WSQQCPSSLE 380 TATDNLPPKV 390 GAPLPPARSD 400 SYAAFRHRER 410 PSSWSSLDQK 420 RLCRPQANSL 430 GSLKSPFIEE 440 QLHTVLEKSP 450 ENSPPVKPKH 460 NYTQKAQPGQ 470 PLLPTSIYPV 480 PSLEPHFAQV 490 PQPSVSSNGM 500 LYPALAKESG 510 YIAPQGACNK 520 MATIDENGNQ 530 NGSGRPGFAF 540 CQPLEHDLLS 550 PVEKKPEATA 560 KYVPSKVHFC 570 SVPENEEDAS 580 LKRHLTPPQG 590 NSPHSNERKS 600 THSNKPSSHP 610 HSLKCPQAQA 620 WQAGEDKRSS 630 RLSEPWEGDF 640 QEDHNANLWR 650 RLEREGLGQS 660 LSGNFGKTKS 670 AFSSLQNIPE 680 SLRRHSSLEL 690 GRGTQEGYPG 700 GRPTCAVNTK 710 AEDPGRKAAP 720 DLGSHLDRQV 730 SYPRPEGRTG 740 ASASFNSTDP 750 SPEEPPAPSH 760 PHTSSLGRRG 770 PGPGSASALQ 780 GFQYGKPHCS 790 VLEKVSKFEQ 800 REQGSQRPSV 810 GGSGFGHNYR 820 PHRTVSTSST 830 SGNDFEETKA 840 HIRFSESAEP 850 LGNGEQHFKN 860 GELKLEEASR 870 QPCGQQLSGG 880 ASDSGRGPQR 890 PDARLLRSQS 900 TFQLSSEPER 910 EPEWRDRPGS 920 PESPLLDAPF 930 SRAYRNSIKD 940 AQSRVLGATS 950 FRRRDLELGA 960 PVASRSWRPR 970 PSSAHVGLRS 980 PEASASASPH 990 TPRERHSVTP 1000 AEGDLARPVP 1010 PAARRGARRR 1020 LTPEQKKRSY 1030 SEPEKMNEVG 1040 IVEEAEPAPL 1050 GPQRNGMRFP 1060 ESSVADRRRL 1070 FERDGKACST 1080 LSLSGPELKQ 1090 FQQSALADYI 1100 QRKTGKRPTS 1110 AAGCSLQEPG 1120 PLRERAQSAY 1130 LQPGPAALEG 1140 SGLASASSLS 1150 SLREPSLQPR 1160 REATLLPATV 1170 AETQQAPRDR 1180 SSSFAGGRRL 1190 GERRRGDLLS 1200 GANGGTRGTQ 1210 RGDETPREPS 1220 SWGARAGKSM 1230 SAEDLLERSD 1240 VLAGPVHVRS 1250 RSSPATADKR 1260 QDVLLGQDSG 1270 FGLVKDPCYL 1280 AGPGSRSLSC 1290 SERGQEEMLP 1300 LFHHLTPRWG 1310 GSGCKAIGDS 1320 SVPSECPGTL 1330 DHQRQASRTP 1340 CPRPPLAGTQ 1350 GLVTDTRAAP 1360 LTPIGTPLPS 1370 AIPSGYCSQD 1380 GQTGRQPLPP 1390 YTPAMMHRSN 1400 GHTLTQPPGP 1410 RGCEGDGPEH 1420 GVEEGTRKRV 1430 SLPQWPPPSR 1440 AKWAHAARED 1450 SLPEESSAPD 1460 FANLKHYQKQ 1470 QSLPSLCSTS 1480 DPDTPLGAPS 1490 TPGRISLRIS 1500 ESVLRDSPPP 1510 HEDYEDEVFV 1520 RDPHPKATSS 1530 PTFEPLPPPP 1540 PPPPSQETPV 1550 YSMDDFPPPP 1560 PHTVCEAQLD 1570 SEDPEGPRPS 1580 FNKLSKVTIA 1590 RERHMPGAAH 1600 VVGSQTLASR 1610 LQTSIKGSEA 1620 ESTPPSFMSV 1630 HAQLAGSLGG 1640 QPAPIQTQSL 1650 SHDPVSGTQG 1660 LEKKVSPDPQ 1670 KSSEDIRTEA 1680 LAKEIVHQDK 1690 SLADILDPDS 1700 RLKTTMDLME 1710 GLFPRDVNLL 1720 KENSVKRKAI 1730 QRTVSSSGCE 1740 GKRNEDKEAV 1750 SMLVNCPAYY 1760 SVSAPKAELL 1770 NKIKEMPAEV 1780 NEEEEQADVN 1790 EKKAELIGSL 1800 THKLETLQEA 1810 KGSLLTDIKL 1820 NNALGEEVEA 1830 LISELCKPNE 1840 FDKYRMFIGD 1850 LDKVVNLLLS 1860 LSGRLARVEN 1870 VLSGLGEDAS 1880 NEERSSLYEK 1890 RKILAGQHED 1900 ARELKENLDR 1910 RERVVLGILA 1920 NYLSEEQLQD 1930 YQHFVKMKST 1940 LLIEQRKLDD 1950 KIKLGQEQVK 1960 CLLESLPSDF 1970 IPKAGALALP 1980 PNLTSEPIPA 1990 GGCTFSGIFP TLTSPL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005912 adherens junction
Cellular Component GO:0043296 apical junction complex
Cellular Component GO:0016324 apical plasma membrane
Cellular Component GO:0030864 cortical actin cytoskeleton
Cellular Component GO:0005856 cytoskeleton
Cellular Component GO:0005874 microtubule
Molecular Function GO:0051015 actin filament binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0045176 apical protein localization
Biological Process GO:0000902 cell morphogenesis
Biological Process GO:0043482 cellular pigment accumulation
Biological Process GO:0007389 pattern specification process
Biological Process GO:0008360 regulation of cell shape

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.