Search Results
Overview
| Uniprot ID | Q8TF76 |
|---|---|
| Protein Name | Serine/threonine-protein kinase haspin |
| Gene Name | HASPIN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 320 | HQEASVPKGRIVPRG |
Function
Serine/threonine-protein kinase that phosphorylates histone H3 at 'Thr-3' (H3T3ph) during mitosis. May act through H3T3ph to both position and modulate activation of AURKB and other components of the chromosomal passenger complex (CPC) at centromeres to ensure proper chromatid cohesion, metaphase alignment and normal progression through the cell cycle
Protein Sequence
10
MAASLPGPGS
20
RLFRTYGAAD
30
GRRQRRPGRE
40
AAQWFPPQDR
50
RRFFNSSGSS
60
DASIGDPSQS
70
DDPDDPDDPD
80
FPGSPVRRRR
90
RRPGGRVPKD
100
RPSLTVTPKR
110
WKLRARPSLT
120
VTPRRLGLRA
130
RPPQKCSTPC
140
GPLRLPPFPS
150
RDSGRLSPDL
160
SVCGQPRDGD
170
ELGISASLFS
180
SLASPCPGSP
190
TPRDSVISIG
200
TSACLVAASA
210
VPSGLHLPEV
220
SLDRASLPCS
230
QEEATGGAKD
240
TRMVHQTRAS
250
LRSVLFGLMN
260
SGTPEDSEFR
270
ADGKNMRESC
280
CKRKLVVGNG
290
PEGPGLSSTG
300
KRRATGQDSC
310
QERGLQEAVR
320
REHQEASVPK
330
GRIVPRGIDR
340
LERTRSSRKS
350
KHQEATETSL
360
LHSHRFKKGQ
370
KLGKDSFPTQ
380
DLTPLQNVCF
390
WTKTRASFSF
400
HKKKIVTDVS
410
EVCSIYTTAT
420
SLSGSLLSEC
430
SNRPVMNRTS
440
GAPSSWHSSS
450
MYLLSPLNTL
460
SISNKKASDA
470
EKVYGECSQK
480
GPVPFSHCLP
490
TEKLQRCEKI
500
GEGVFGEVFQ
510
TIADHTPVAI
520
KIIAIEGPDL
530
VNGSHQKTFE
540
EILPEIIISK
550
ELSLLSGEVC
560
NRTEGFIGLN
570
SVHCVQGSYP
580
PLLLKAWDHY
590
NSTKGSANDR
600
PDFFKDDQLF
610
IVLEFEFGGI
620
DLEQMRTKLS
630
SLATAKSILH
640
QLTASLAVAE
650
ASLRFEHRDL
660
HWGNVLLKKT
670
SLKKLHYTLN
680
GKSSTIPSCG
690
LQVSIIDYTL
700
SRLERDGIVV
710
FCDVSMDEDL
720
FTGDGDYQFD
730
IYRLMKKENN
740
NRWGEYHPYS
750
NVLWLHYLTD
760
KMLKQMTFKT
770
KCNTPAMKQI
780
KRKIQEFHRT
790
MLNFSSATDL
LCQHSLFK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005819 | spindle |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0072354 | histone H3T3 kinase activity |
| Molecular Function | GO:0004672 | protein kinase activity |
| Molecular Function | GO:0106310 | protein serine kinase activity |
| Biological Process | GO:0035556 | intracellular signal transduction |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0007064 | mitotic sister chromatid cohesion |
| Biological Process | GO:0007094 | mitotic spindle assembly checkpoint signaling |
| Biological Process | GO:0071459 | protein localization to chromosome, centromeric region |
| Biological Process | GO:0006468 | protein phosphorylation |
Reference
PMID: N/A