Search Results

Overview

Uniprot ID	Q8VCW8
Protein Name	Medium-chain acyl-CoA ligase ACSF2, mitochondrial
Gene Name	Acsf2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
182	IVFPKQFKTQQYYDI
340	SPSFNGKKALEAISR
510	CKIVGRSKDMIIRGG

Function

Acyl-CoA synthases catalyze the initial reaction in fatty acid metabolism, by forming a thioester with CoA. Has some preference toward medium-chain substrates. Plays a role in adipocyte differentiation

Protein Sequence

10 MAVYHGMLRF 20 GRLCIASLGA 30 RGPRTLLSRP 40 RPNSKLQSVR 50 ALSSGMVNCT 60 NPLPIGGLSY 70 IQGHTDSHLV 80 NTTVGECLDA 90 TAQRFPDREA 100 LVILHENIRL 110 NFAQLKEEVD 120 KAASGLLSIG 130 LRKGDRLGMW 140 GPNSYAWVLI 150 QLATAQAGII 160 LVSVNPAYQS 170 SELEYVLRKV 180 GCKGIVFPKQ 190 FKTQQYYDIL 200 KQVCPELEKA 210 QPGALKSERL 220 PDLTTVISVD 230 APLPGTLLLD 240 DIVAAGGKEQ 250 NLAQLRYNQR 260 FLSCYDPINI 270 QFTSGTTGNP 280 KGATLSHHNI 290 VNNSMLIGQR 300 LKMPTKTAEE 310 LRLVLPSPLY 320 HCLGSVGGTM 330 VSMMHGATLL 340 LSSPSFNGKK 350 ALEAISREKG 360 TLLYGTPTMF 370 VDILNQPDFS 380 SYDFTSIRGG 390 VIAGSPAPPE 400 LIRAIINKMN 410 MKELVVVYGT 420 TENSPVTFMN 430 FPEDTLEQKA 440 GSVGRIMPHT 450 EAQIVNVETG 460 ELTNLNVPGE 470 LYIRGYCVMQ 480 GYWGEPQKTF 490 ETVGQDKWYR 500 TGDIALMDEQ 510 GFCKIVGRSK 520 DMIIRGGENI 530 YPAELEDFFL 540 KHPQVQEAQV 550 VGVKDERMGE 560 EICACIRLKS 570 GETTTAEEIK 580 AFCKGKISHF 590 KIPRYIVFVE 600 GYPLTISGKI 610 QKFKLREQME QHLKL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0031956	medium-chain fatty acid-CoA ligase activity
Biological Process	GO:0006631	fatty acid metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.