Search Results

Overview

Uniprot ID	Q8VDC0
Protein Name	Probable leucine--tRNA ligase, mitochondrial
Gene Name	Lars2
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
332	SVKKALQKALVPGRD
719	QPQLLNSKEKTKAQN

Function

No function data available.

Protein Sequence

10 MASTCQRLSF 20 YVSPLKRQLV 30 SRPPVILWER 40 LIPGCSRSIY 50 SATGKWTKEY 60 TLQTRKDVEK 70 WWHQQIKEQA 80 SRVSEEDKLK 90 PKFYLLSMFP 100 YPSGKLHMGH 110 VRVYTLSDTI 120 ARFQKMRGMQ 130 VINPMGWDAF 140 GLPAENAAIE 150 RNLHPESWTQ 160 SNIKHMRKQL 170 DRLGLCFSWD 180 REITTCLPDY 190 YKWTQYLFIK 200 LYEAGLAYQK 210 EALVNWDPVD 220 QTVLANEQVN 230 EYGCSWRSGA 240 KVEKKYLRQW 250 FIKTTAYAKA 260 MQDALADLPE 270 WYGIKGMQAH 280 WIGDCVGCHL 290 DFTLKVDGED 300 TGEKLTAYTA 310 TPEAIYGISH 320 VAISPSHGLL 330 HGCSSVKKAL 340 QKALVPGRDC 350 LTPVMAVSML 360 TLQEVPIVIM 370 ANPDLEGSLD 380 SKIGIPSTSS 390 EDTRLAQALG 400 LPYSEVIEAS 410 PDGTERLSGS 420 AEFTGMTRQD 430 AFVALTRKAR 440 GMRVGGHVTS 450 NKLKDWLISR 460 QRYWGTPIPI 470 VHCPACGPVP 480 VPLQDLPVIL 490 PSIASLTGRG 500 GSPLATALEW 510 VNCSCPRCKG 520 SAKRETDTMD 530 TFVDSAWYYF 540 RYTDPHNTQS 550 PFGSALADFW 560 MPVDLYIGGK 570 EHAVMHLFYA 580 RFLSHFCHDQ 590 KMVKHREPFH 600 KLLAQGLIKG 610 QTFRLPSGQC 620 LKKEDIDFTG 630 PAPVCAKTKE 640 KLEVTWEKMS 650 KSKHNGVDPE 660 EIVAQYGIDT 670 IRLYILFAAP 680 PEKDILWDVK 690 TDALPGVLRW 700 QQRLWSLTTR 710 FIEARTSGTV 720 PQPQLLNSKE 730 KTKAQNLWEY 740 KNAVIAQVTT 750 HFTEDFALNS 760 VVSQLMGLSS 770 ALSQASQRVV 780 LHSPEFEDAL 790 CALLVMAAPL 800 APHVTSELWA 810 GLTLVPSKLC 820 DHYAWDSGVM 830 LQAWPTVDSQ 840 FLQKPDMVQM 850 AVLINNKACG 860 KIPVPQHVAQ 870 DQDKVHELVL 880 QSELGMKLLQ 890 GRSIKKAFLS 900 PRTALINFLV QE

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Molecular Function	GO:0002161	aminoacyl-tRNA deacylase activity
Molecular Function	GO:0005524	ATP binding
Molecular Function	GO:0004823	leucine-tRNA ligase activity
Biological Process	GO:0006429	leucyl-tRNA aminoacylation
Biological Process	GO:0032543	mitochondrial translation

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.