Search Results
Overview
| Uniprot ID | Q8VEE1 |
|---|---|
| Protein Name | LIM and cysteine-rich domains protein 1 |
| Gene Name | Lmcd1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 6 | **MAKVAKDLNPGVQ |
Function
Transcriptional cofactor that restricts GATA6 function by inhibiting DNA-binding, resulting in repression of GATA6 transcriptional activation of downstream target genes. Represses GATA6-mediated trans activation of lung- and cardiac tissue-specific promoters. Inhibits DNA-binding by GATA4 and GATA1 to the cTNC promoter. Plays a critical role in the development of cardiac hypertrophy via activation of calcineurin/nuclear factor of activated T-cells signaling pathway
Protein Sequence
10
MAKVAKDLNP
20
GVQKMSLGQQ
30
QSARGVACLR
40
CKGMCSGFEP
50
HSWRKICKSC
60
KCSQEEHCLS
70
SDLDDDRKIG
80
RLLMDSKYAT
90
LTARVKGGDG
100
IRIYKRNRMI
110
MTNPIATGKD
120
PTFDTITYEW
130
APPGVTQKLG
140
LQYMELIPKE
150
RQPVTGTEGA
160
LYRRRQLMHQ
170
LPIYDQDPSR
180
CRGLVENELK
190
AMEEFVKHYK
200
SEALGVGEVA
210
LPGQGGLPKE
220
ENKTQEKPEG
230
TETTAPTTNG
240
SLGDPSKEVE
250
YVCELCKGAA
260
PVDSPVVYAD
270
RAGYSKQWHP
280
TCFQCIKCSE
290
PLVDLIYFWK
300
DGAPWCGRHY
310
CESVRPRCSG
320
CDEIIFSEDY
330
QRVEDLAWHR
340
KHFICEGCEQ
350
LLSGRAYIVT
360
KGQLLCPTCS
KSKRS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003714 | transcription corepressor activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade |
| Biological Process | GO:0010611 | regulation of cardiac muscle hypertrophy |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.