Search Results

Overview

Uniprot IDQ8VEM8
Protein NameSolute carrier family 25 member 3
Gene NameSlc25a3
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
201 TLREAVPKMYKEEGL
204 EAVPKMYKEEGLNAF
247 LYKFVVPKPRSECTK
290 VSVLNKEKGSTASQV
308 LGFRGVWKGLFARII
94 RMQVDPQKYKGIFNG

Function

Inorganic ion transporter that transports phosphate or copper ions across the mitochondrial inner membrane into the matrix compartment (By similarity). Mediates proton-coupled symport of phosphate ions necessary for mitochondrial oxidative phosphorylation of ADP to ATP (By similarity). Transports copper ions probably in the form of anionic copper(I) complexes to maintain mitochondrial matrix copper pool and to supply copper for cytochrome C oxidase complex assembly (PubMed:29237729). May also play a role in regulation of the mitochondrial permeability transition pore (mPTP) (By similarity)

Protein Sequence

10 MFSSVAHLAR 20 ANPFNAPHLQ 30 LVHDGLSGPR 40 SPPAPPRRSR 50 HLAAAAVEEY 60 SCEFGSMKYY 70 ALCGFGGVLS 80 CGLTHTAVVP 90 LDLVKCRMQV 100 DPQKYKGIFN 110 GFSITLKEDG 120 VRGLAKGWAP 130 TLIGYSMQGL 140 CKFGFYEVFK 150 ALYSNILGEE 160 NTYLWRTSLY 170 LASSASAEFF 180 ADIALAPMEA 190 AKVRIQTQPG 200 YANTLREAVP 210 KMYKEEGLNA 220 FYKGVAPLWM 230 RQIPYTMMKF 240 ACFERTVEAL 250 YKFVVPKPRS 260 ECTKAEQLVV 270 TFVAGYIAGV 280 FCAIVSHPAD 290 SVVSVLNKEK 300 GSTASQVLQR 310 LGFRGVWKGL 320 FARIIMIGTL 330 TALQWFIYDS 340 VKVYFRLPRP 350 PPPEMPESLK KKLGLTE

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Molecular Function GO:0005315 phosphate transmembrane transporter activity
Molecular Function GO:0015317 phosphate:proton symporter activity
Molecular Function GO:0044877 protein-containing complex binding
Biological Process GO:1990547 mitochondrial phosphate ion transmembrane transport
Biological Process GO:0035435 phosphate ion transmembrane transport

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.