Search Results

Overview

Uniprot IDQ8VHX6
Protein NameFilamin-C
Gene NameFlnc
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
2700 YNVTYTVKEKGDYIL
912 VHFAGAAKGEAVRDF

Function

Muscle-specific filamin, which plays a central role in sarcomere assembly and organization (By similarity). Critical for normal myogenesis, it probably functions as a large actin-cross-linking protein with structural functions at the Z lines in muscle cells. May be involved in reorganizing the actin cytoskeleton in response to signaling events (PubMed:16914736)

Protein Sequence

10 MMNNSNYSDA 20 SGLGLVDEAD 30 EMPSTEKDLA 40 EDAPWKKIQQ 50 NTFTRWCNEH 60 LKCVGKRLTD 70 LQRDLSDGLR 80 LIALLEVLSQ 90 KRMYRKFHPR 100 PNFRQMKLEN 110 VSVALEFLER 120 EHIKLVSIDS 130 KAIVDGNLKL 140 ILGLIWTLIL 150 HYSISMPMWE 160 DEDDEDARKQ 170 TPKQRLLGWI 180 QNKVPQLPIT 190 NFNRDWQDGK 200 ALGALVDNCA 210 PGLCPDWEAW 220 DPNQPVQNAR 230 EAMQQADDWL 240 GVPQVIAPEE 250 IVDPNVDEHS 260 VMTYLSQFPK 270 AKLKPGAPVR 280 SKQLNPKKAI 290 AYGPGIEPQG 300 NTVLQPAHFT 310 VQTVDAGVGE 320 VLVYIEDPEG 330 HTEEAKVVPN 340 NDKDRTYAVS 350 YVPKVAGLHK 360 VTVLFAGQNI 370 ERSPFEVNVG 380 MALGDANKVS 390 ARGPGLEPVG 400 NVANKPTYFD 410 IYTAGAGTGD 420 VAVVIVDPQG 430 RRDTVEVALE 440 DKGDNTFRCT 450 YRPVMEGPHT 460 VHVAFAGAPI 470 TRSPFPVHVA 480 EACNPNACRA 490 SGRGLQPKGV 500 RVKEVADFKV 510 FTKGAGSGEL 520 KVTVKGPKGT 530 EEPVKVREAG 540 DGVFECEYYP 550 VVPGKYVVTI 560 TWGGYAIPRS 570 PFEVQVSPEA 580 GAQKVRAWGP 590 GLETGQVGKS 600 ADFVVEAIGT 610 EVGTLGFSIE 620 GPSQAKIECD 630 DKGDGSCDVR 640 YWPTEPGEYA 650 VHVICDDEDI 660 RDSPFIAHIQ 670 PAPPDCFPDK 680 VKAFGPGLEP 690 TGCIVDRPAE 700 FTIDARAAGK 710 GDLKLYAQDA 720 DGCPIDIKVI 730 PNGDGTFRCS 740 YVPTKPIKHT 750 IIVSWGGVNV 760 PKSPFRVNVG 770 EGSHPERVKV 780 YGPGVEKTGL 790 KANEPTYFTV 800 DCSEAGQGDV 810 SIGIKCAPGV 820 VGPVEADIDF 830 DIIKNDNDTF 840 TVKYTPPGAG 850 HYTIMVLFAN 860 QEIPASPFHI 870 KVDPSHDASK 880 VKAEGPGLSR 890 TGVEVGKPTH 900 FTVLTKGAGK 910 AKLDVHFAGA 920 AKGEAVRDFE 930 IIDNHDYSYT 940 VKYTAVQQGN 950 MAVTVTYGGD 960 PVPKSPFVVN 970 VAPPLDLSKV 980 KVQGLNSKVA 990 VGQEQAFSVN 1000 TRGAGGQGQL 1010 DVRMTSPSRR 1020 PIPCKLEPGG 1030 GAEAQAVRYM 1040 PPEEGPYKVD 1050 ITYDGHPVPG 1060 SPFAVEGVLP 1070 PDPSKVCAYG 1080 PGLKGGLVGT 1090 PAPFSIDTKG 1100 AGTGGLGLTV 1110 EGPCEAKIEC 1120 QDNGDGSCAV 1130 SYLPTEPGEY 1140 TINILFAEAH 1150 IPGSPFKATI 1160 QPVFDPSKVR 1170 ASGPGLERGK 1180 AGEAATFTVD 1190 CSEAGEAELT 1200 IEILSDAGVK 1210 AEVLIQNNAD 1220 GTYHITYSPA 1230 FPGTYTITIK 1240 YGGHPIPKFP 1250 TRVHVQPAVD 1260 TSGIKVSGPG 1270 VEPHGVLREV 1280 TTEFTVDARS 1290 LTATGGNHVT 1300 ARVLNPSGAK 1310 TDTYVTDNGD 1320 GTYRVQYTAY 1330 EEGVHLVEVL 1340 YDEVAVPKSP 1350 FRVGVTEGCD 1360 PTRVRAFGPG 1370 LEGGLVNKAN 1380 RFTVETRGAG 1390 TGGLGLAIEG 1400 PSEAKMSCKD 1410 NKDGSCTVEY 1420 IPFTPGDYDV 1430 NITFGGQPIP 1440 GSPFRVPVKD 1450 VVDPGKVKCS 1460 GPGLGTGVRA 1470 RVPQTFTVDC 1480 SQAGRAPLQV 1490 AVLGPTGVAE 1500 PVEVRDNGDG 1510 THTVHYTPAT 1520 DGPYTVAVKY 1530 ADQEVPRSPF 1540 KIKVLPSHDA 1550 SKVRASGPGL 1560 NASGIPASLP 1570 VEFTIDARDA 1580 GQGLLTVQIL 1590 DPEGKPKKAN 1600 IRDNGDGTYT 1610 VSYLPDMSGR 1620 YTITIKYGGD 1630 EIPYSPFRIH 1640 ALPTGDASKC 1650 LVTVSIGGHG 1660 LGACLGPRIQ 1670 IGEETVITVD 1680 AKAAGKGKVT 1690 CTVSTPDGAE 1700 LDVDVVENHD 1710 GTFDIYYTAP 1720 EPGKYVITIR 1730 FGGEHIPNSP 1740 FHVLACDPLP 1750 HVEEPAEMLQ 1760 MRQPYAPLRP 1770 GTCPTHWATE 1780 EPVVPVEPLE 1790 SMLRPFNLVI 1800 PFTVQKGELT 1810 GEVRMPSGKT 1820 ARPNITDNKD 1830 GTITVRYAPT 1840 EKGLHQMGIK 1850 YDGNHIPGSP 1860 LQFYVDAINS 1870 RHVSAYGPGL 1880 SHGMVNKPAT 1890 FTIVTKDAGE 1900 GGLSLAVEGP 1910 SKAEITCKDN 1920 KDGTCTVSYL 1930 PTAPGDYSII 1940 VRFDDKHIPG 1950 SPFTAKITGD 1960 DSMRTSQLNV 1970 GTSTDVSLKI 1980 TEGDLSQLTA 1990 SIRAPSGNEE 2000 PCLLKRLPNR 2010 HIGISFTPKE 2020 VGEHVVSVRK 2030 SGKHVTNSPF 2040 KILVGPSEIG 2050 DASKVRVWGK 2060 GLSEGQTFQV 2070 AEFIVDTRNA 2080 GYGGLGLSIE 2090 GPSKVDINCE 2100 DMEDGTCKVT 2110 YCPTEPGTYI 2120 INIKFADKHV 2130 PGSPFTVKVT 2140 GEGRMKESIT 2150 RRRQAPSIAT 2160 IGSTCDLNLK 2170 IPGNWFQMVS 2180 AQERLTRTFT 2190 RSSHTYTRTE 2200 RTEISKTRGG 2210 ETKREVRVEE 2220 STQVGGDPFP 2230 AVFGDFLGRE 2240 RLGSFGSITR 2250 QQEGEASSQD 2260 MTAQVTSPSG 2270 KTEAAEIVEG 2280 EDSAYSVRFV 2290 PQEMGPHTVT 2300 VKYRGQHVPG 2310 SPFQFTVGPL 2320 GEGGAHKVRA 2330 GGTGLERGVA 2340 GVPAEFSIWT 2350 REAGAGGLSI 2360 AVEGPSKAEI 2370 AFEDRKDGSC 2380 GVSYVVQEPG 2390 DYEVSIKFND 2400 EHIPDSPFVV 2410 PVASLSDDAR 2420 RLTVTSLQET 2430 GLKVNQPASF 2440 AVQLNGARGV 2450 IDARVHTPSG 2460 AVEECYVSEL 2470 DSDKHTIRFI 2480 PHENGVHSID 2490 VKFNGAHIPG 2500 SPFKIRVGEQ 2510 SQAGDPGLVS 2520 AYGPGLEGGT 2530 TGVSSEFIVN 2540 TQNAGSGALS 2550 VTIDGPSKVQ 2560 LDCRECPEGH 2570 VVTYTPMAPG 2580 NYLIAIKYGG 2590 PQHIVGSPFK 2600 AKVTGPRLSG 2610 GHSLHETSTV 2620 LVETVTKSSS 2630 SRGASYSSIP 2640 KFSSDASKVV 2650 TRGPGLSQAF 2660 VGQKNSFTVD 2670 CSKAGTNMMM 2680 VGVHGPKTPC 2690 EEVYVKHMGN 2700 RVYNVTYTVK 2710 EKGDYILIVK 2720 WGDESVPGSP FKVNVP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015629 actin cytoskeleton
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0045171 intercellular bridge
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0042383 sarcolemma
Cellular Component GO:0016528 sarcoplasm
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003779 actin binding
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0030506 ankyrin binding
Molecular Function GO:0008092 cytoskeletal protein binding
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0030029 actin filament-based process
Biological Process GO:0055001 muscle cell development
Biological Process GO:0045214 sarcomere organization

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.