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Overview

Uniprot IDQ8WTR7
Protein NameZinc finger protein 473
Gene NameZNF473
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
512 HQKMHTVKTPYECQE

Function

Involved in histone 3'-end pre-mRNA processing by associating with U7 snRNP and interacting with SLBP/pre-mRNA complex. Increases histone 3'-end pre-mRNA processing but has no effect on U7 snRNP levels, when overexpressed. Required for cell cycle progression from G1 to S phases

Protein Sequence

10 MAEEFVTLKD 20 VGMDFTLGDW 30 EQLGLEQGDT 40 FWDTALDNCQ 50 DLFLLDPPRP 60 NLTSHPDGSE 70 DLEPLAGGSP 80 EATSPDVTET 90 KNSPLMEDFF 100 EEGFSQEIIE 110 MLSKDGFWNS 120 NFGEACIEDT 130 WLDSLLGDPE 140 SLLRSDIATN 150 GESPTECKSH 160 ELKRGLSPVS 170 TVSTGEDSMV 180 HNVSEKTLTP 190 AKSKEYRGEF 200 FSYSDHSQQD 210 SVQEGEKPYQ 220 CSECGKSFSG 230 SYRLTQHWIT 240 HTREKPTVHQ 250 ECEQGFDRNA 260 SLSVYPKTHT 270 GYKFYVCNEY 280 GTTFSQSTYL 290 WHQKTHTGEK 300 PCKSQDSDHP 310 PSHDTQPGEH 320 QKTHTDSKSY 330 NCNECGKAFT 340 RIFHLTRHQK 350 IHTRKRYECS 360 KCQATFNLRK 370 HLIQHQKTHA 380 AKTTSECQEC 390 GKIFRHSSLL 400 IEHQALHAGE 410 EPYKCNERGK 420 SFRHNSTLKI 430 HQRVHSGEKP 440 YKCSECGKAF 450 HRHTHLNEHR 460 RIHTGYRPHK 470 CQECVRSFSR 480 PSHLMRHQAI 490 HTAEKPYSCA 500 ECKETFSDNN 510 RLVQHQKMHT 520 VKTPYECQEC 530 GERFICGSTL 540 KCHESVHARE 550 KQGFFVSGKI 560 LDQNPEQKEK 570 CFKCNKCEKT 580 FSCSKYLTQH 590 ERIHTRGVKP 600 FECDQCGKAF 610 GQSTRLIHHQ 620 RIHSRVRLYK 630 WGEQGKAISS 640 ASLIKLQSFH 650 TKEHPFKCNE 660 CGKTFSHSAH 670 LSKHQLIHAG 680 ENPFKCSKCD 690 RVFTQRNYLV 700 QHERTHARKK 710 PLVCNECGKT 720 FRQSSCLSKH 730 QRIHSGEKPY 740 VCDYCGKAFG 750 LSAELVRHQR 760 IHTGEKPYVC 770 QECGKAFTQS 780 SCLSIHRRVH 790 TGEKPYRCGE 800 CGKAFAQKAN 810 LTQHQRIHTG 820 EKPYSCNVCG 830 KAFVLSAHLN 840 QHLRVHTQET 850 LYQCQRCQKA 860 FRCHSSLSRH 870 QRVHNKQQYC L

Gene Ontology

Classification GO ID Description
Cellular Component GO:0015030 Cajal body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0000976 transcription cis-regulatory region binding
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage
Biological Process GO:0000122 negative regulation of transcription by RNA polymerase II

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.